Stress, Corticotrophin-Releasing Factor (CRF) and Gastric Function

  • Herbert Weiner
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 2)


Selye1 demonstrated that many different kinds of “stressors” were associated with the development of gastric erosions (GE’s) in the rat. Since that time the number of methods for producing GE’s in the rat has grown exponentially2–4. Initially, the burden of the pathogenesis of GE was placed on the corticosteroids and on increases in gastric acid secretion (GAS). Yet, Cannon in 1929 first showed that GAS was reduced in the threatened cat. Since that time many different (stressful) perturbations of a physical and psychobiological nature have been shown to reduce GAS (reviewed in 5): They include restraining or rotating rats, exposing them to unpredictable electric shock or making them avoid it in free-operant experiments, confronting them with an aggressive opponent, or housing them in a hot environment.


Gastric Acid Secretion Gastric Function Dorsal Vagal Complex Gastric Blood Flow64 Gastric Contraction 
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  • Herbert Weiner

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