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Adhesion Molecules Involved in the Extravasation of Lymphocytes in Lymphoid Organs and Chronically Inflamed Tissues

  • Chapter
Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin

Part of the book series: NATO ASI Series ((NSSA,volume 265))

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Abstract

Cell adhesion molecules play an important role in many cellular processes, such as sperm-egg binding, organogenesis (Hoffmann et al., 1982) and lymphocyte migration (Springer, 1990; Albelda, 1991). Furthermore, in the immune system, they are crucial in T lymphocyte-accessory cell and T lymphocyte-target cell interactions which are required, respectively, for the induction of immune responses or for effector cell function (Dustin et al., 1987; Springer et al., 1987; Martz, 1987). They also mediate a variety of other, non-antigen-specific, cell-cell and cell-substrate interactions in the immune system, including lymphocyte adhesion to endothelium during lymphocyte recirculation through lymphoid organs and lymphocyte extravasation in chronic inflammation (Stoolman, 1989; Chin et al., 1990; Jalkanen et al., 1990). Here we will highlight the role of cell adhesion molecules in lymphocyte — endothelium interactions in lymphocyte extravasation in lymph nodes and in chronically inflamed tissues.

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Authors and Affiliations

  1. Department of Pathology, Free University Hospital, The Netherlands

    A. C. H. M. van Dinther-Janssen & R. J. Scheper

  2. Department of Histology Faculty of Medicine, Free University, The Netherlands

    G. Kraal

  3. Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands

    R. Willemze & C. J. L. M. Meijer

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  1. A. C. H. M. van Dinther-Janssen
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  2. G. Kraal
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  3. R. J. Scheper
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  4. R. Willemze
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  5. C. J. L. M. Meijer
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Editors and Affiliations

  1. UMD-New Jersey Medical School, Newark, New Jersey, USA

    W. Clark Lambert

  2. University of Florence, Florence, Italy

    Benvenuto Giannotti

  3. University Hospital, Utrecht, Utrecht, The Netherlands

    Willem A. van Vloten

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van Dinther-Janssen, A.C.H.M., Kraal, G., Scheper, R.J., Willemze, R., Meijer, C.J.L.M. (1994). Adhesion Molecules Involved in the Extravasation of Lymphocytes in Lymphoid Organs and Chronically Inflamed Tissues. In: Lambert, W.C., Giannotti, B., van Vloten, W.A. (eds) Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. NATO ASI Series, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1861-7_9

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