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Cell Trafficking Networks in Cutaneous T Cell Lymphoma

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Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin

Part of the book series: NATO ASI Series ((NSSA,volume 265))

Abstract

An extensive network of Thy-1+/Factor XIIIa+ dermal dendrocytes (DD) (Table 1) exists within the papillary dermis in lesions of cutaneous T cell lymphoma (CTCL). To further characterize these cells and to study the role that activation signals and adhesion molecules play in the cellular dynamics of CTCL, immunohistochemical staining of formalin fixed, paraffin embedded tissue sections was used to study expression of high endothelial cell antigen-1 (HECA-452) and proliferating cell nuclear antigen (PCNA) in lesions of CTCL as compared to those of psoriasis, Rhus dermatitis and normal skin. In diseased skin, 10–60% of epidermotropic lymphocytes were PCNA+, comparable to the numbers of Ki-67+ and human mucosal leukocyte antigen (HML)-1+ cells seen in previous studies. HECA-452 expression by dermal lymphocytes ranged from 1–42%. Only in lesions of CTCL were appreciable numbers of epidermal HECA-452+ lymphocytes present (mean = 31%+). PCNA+ lymphocytes were routinely seen only in CTCL and were limited to a subset of cells within the epidermis.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA

    David P. Fivenson M. D.

  2. Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA

    Brian J. Nickoloff M. D., Ph.D.

Authors
  1. David P. Fivenson M. D.
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  2. Brian J. Nickoloff M. D., Ph.D.
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Editor information

Editors and Affiliations

  1. UMD-New Jersey Medical School, Newark, New Jersey, USA

    W. Clark Lambert

  2. University of Florence, Florence, Italy

    Benvenuto Giannotti

  3. University Hospital, Utrecht, Utrecht, The Netherlands

    Willem A. van Vloten

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© 1994 Springer Science+Business Media New York

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Fivenson, D.P., Nickoloff, B.J. (1994). Cell Trafficking Networks in Cutaneous T Cell Lymphoma. In: Lambert, W.C., Giannotti, B., van Vloten, W.A. (eds) Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. NATO ASI Series, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1861-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-1861-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5756-8

  • Online ISBN: 978-1-4615-1861-7

  • eBook Packages: Springer Book Archive

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