Abstract
Karyotyping of peripheral blood leucocytes of patients with Sézary syndrome often reveals cells with multiple chromosome changes primarily characterized by the existence of several structurally abnormal chromosomes (marker chromosomes). Here we show that these cells represent malignant T cells. Malignant T cells with multiple and complex chromosomal aberrations belong to a family of T cells for which we suggest the name “genotraumatic T cells”. A genotraumatic T cell, unlike a normal T lymphocyte, is characterized by its ability to develop clonal chromsomal aberrations. We propose that a genotraumatic T cell generates by successive cell divisions multiple and complex chromosome aberrations. Surprisingly, several different genotraumatic T cell clones may exist in a given patient. Genotraumatic T cells are also detected in patients with mycosis fungoides.
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Kaltoft, K., Bisballe, S., Sterry, W., Søgaard, H., Thestrup-Pedersen, K. (1994). Sézary Syndrome is Characterized by Genotraumatic T Cells. In: Lambert, W.C., Giannotti, B., van Vloten, W.A. (eds) Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. NATO ASI Series, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1861-7_33
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DOI: https://doi.org/10.1007/978-1-4615-1861-7_33
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