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Sézary Syndrome is Characterized by Genotraumatic T Cells

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Book cover Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin

Part of the book series: NATO ASI Series ((NSSA,volume 265))

Abstract

Karyotyping of peripheral blood leucocytes of patients with Sézary syndrome often reveals cells with multiple chromosome changes primarily characterized by the existence of several structurally abnormal chromosomes (marker chromosomes). Here we show that these cells represent malignant T cells. Malignant T cells with multiple and complex chromosomal aberrations belong to a family of T cells for which we suggest the name “genotraumatic T cells”. A genotraumatic T cell, unlike a normal T lymphocyte, is characterized by its ability to develop clonal chromsomal aberrations. We propose that a genotraumatic T cell generates by successive cell divisions multiple and complex chromosome aberrations. Surprisingly, several different genotraumatic T cell clones may exist in a given patient. Genotraumatic T cells are also detected in patients with mycosis fungoides.

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Authors and Affiliations

  1. Department of Dermatology, Institute of Human Genetics, The Bartholin Building, Aarhus C, Denmark

    Keld Kaltoft & Susanne Bisballe

  2. Department of Dermatology, Aarhus University, DK-8000, Aarhus C, Denmark

    Kristian Thestrup-Pedersen

  3. Aarhus Municipal Hospital, Denmark

    Helmer Søgaard

  4. Department of Dermatology, University of Ulm, Germany

    Wolfram Sterry

Authors
  1. Keld Kaltoft
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  2. Susanne Bisballe
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  3. Wolfram Sterry
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  4. Helmer Søgaard
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  5. Kristian Thestrup-Pedersen
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Editor information

Editors and Affiliations

  1. UMD-New Jersey Medical School, Newark, New Jersey, USA

    W. Clark Lambert

  2. University of Florence, Florence, Italy

    Benvenuto Giannotti

  3. University Hospital, Utrecht, Utrecht, The Netherlands

    Willem A. van Vloten

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© 1994 Springer Science+Business Media New York

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Kaltoft, K., Bisballe, S., Sterry, W., Søgaard, H., Thestrup-Pedersen, K. (1994). Sézary Syndrome is Characterized by Genotraumatic T Cells. In: Lambert, W.C., Giannotti, B., van Vloten, W.A. (eds) Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. NATO ASI Series, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1861-7_33

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  • DOI: https://doi.org/10.1007/978-1-4615-1861-7_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5756-8

  • Online ISBN: 978-1-4615-1861-7

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