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BCL-2 Gene Rearrangement and Protein Expression in Primary Cutaneous B Cell Lymphomas

  • F. Pezzella
  • M. Santucci
  • A. Neri
  • D. Trecca
  • M. Jones
  • E. Berti
Part of the NATO ASI Series book series (NSSA, volume 265)

Abstract

Primary cutaneous B cell lymphomas (CBCLs) have been recently identified on the basis of their clinical, histological, phenotypic and genotypic features. CBCLs usually show a slow progression with a benign evolution in most cases. Cytological features vary from small lymphocytic to large cell lymphomas. Phenotypic and genotypic data provide evidence for clonal proliferation of mature B lymphocytes. The aim of our study was to analyze the occurrences of bcl-2 gene rearrangement and protein expression in a large series of CBCLs, including many follicular lymphomas. Our results show that only 60% of the CBCLs are positive for bcl-2 protein. Interestingly enough, the small cell lymphomas were all strongly stained, whereas 60% of the large cell lymphomas were negative. Furthermore, only one of 20 follicular CBCLs analyzed showed bcl-2 rearrangement using probes for the major breakpoint region (pFL-1). The pattern of bcl-2 expression observed in primary cutaneous lymphomas, and the absence of bcl-2 gene rearrangement, suggest a similarity between these tumors and MALT B cell lymphomas.

Keywords

Cell Lymphoma Mucosa Associate Lymphoid Tissue Mucosa Associate Lymphoid Tissue Lymphoma Breakpoint Cluster Region Primary Cutaneous Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • F. Pezzella
    • 1
  • M. Santucci
    • 2
  • A. Neri
    • 3
  • D. Trecca
    • 3
  • M. Jones
    • 1
  • E. Berti
    • 4
  1. 1.Department of HematologyJohn Radcliffe HospitalOxfordEngland
  2. 2.Institute of Morbid Anatomy and HistopathologyUniversity of FlorenceFlorenceItaly
  3. 3.Institute of Medical ScienceUniversity of MilanoMilanItaly
  4. 4.First Department of DermatologyUniversity of MilanoMilanItaly

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