Abstract
Several years ago, our laboratory reported isolation of a virus, HTLV-5, from a Tacnegative T-cell lymphoma/leukemia. To date, however, no cell line has been obtained which consistently produces amounts of virus sufficient to permit detection of reverse transcriptase (RT) or to form the basis for a serologic test. In the process of attempting to develop such a cell line, we found that the lymphocyte cell line, GB, derived from a patient with cutaneous lymphoma/leukemia, produces an inhibitor of RT. Production of this inhibitory factor is transmitted, both by infection and by transfection, to cell lines which do not produce it spontaneously.
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References
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© 1994 Springer Science+Business Media New York
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Manzari, V., Albonici, L., Ciotti, M., Lombardi, M.P., Silvestri, I. (1994). A New Retrovirus from Cutaneous T-Cell Lymphoma. In: Lambert, W.C., Giannotti, B., van Vloten, W.A. (eds) Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin. NATO ASI Series, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1861-7_12
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DOI: https://doi.org/10.1007/978-1-4615-1861-7_12
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