Evidence for Presynaptic Damage in Myasthenia Gravis
Myasthenia Gravis (MG) has been considered as an autoimmune disease at neuromuscular junction caused by circulating antibodies to acetylcholine receptors (AchR) since 1973. Antibodies to AchR can be detected in 65–95 % sera from patients with MG. In the mean time, no correlation between the antibodies titer and severity of symptoms of the disease was found. Experiemntal myasthenia gravis (EAMG) not only can be induced by injection of antibodies to AchR positive sera from MG patients, but also can be induced by injecting sera with undetectable antibody to AchR. The last few years, we looked into other factors in the pathogenesis of myasthenia Gravis.
KeywordsAntibody Titer Neuromuscular Junction Normal Plasma Wheat Germ Agglutinin Demyelinating Disease
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