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Cellular Physiology of Epileptogenic Phenomena

A Hint for Future Therapy by a Herbal Mixture
  • Eiichi Sugaya
  • Aiko Sugaya
  • Kagemasa Kajiwara
  • Tadashi Tsuda
  • Noriyo Kubota
  • Noriyuki Yuyama
  • Masahiro Motoki
  • Tamaki Takagi
  • Hisaaki Takagi
  • Tamiko Ookura
  • Hideko Nagasawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 363)

Abstract

Epilepsy is one of the most frequently occurring nervous diseases. One out of 200 persons suffers from epilepsy. Nevertheless, there is still no definite radical therapy against epilepsy. Actual therapy against epilepsy is merely the expectation of a spontaneous cure by long-term inhibition of convulsions that facilitate the next convulsions using so-called anticonvulsant drugs, even when patients are tortured with side effects. To achieve a reasonable radical therapy, it is dispensable to elucidate the process of intracellular change of normal regular firing neurons into seizure-evoking neurons; and the differences between neurons manifesting bursting activity and those showing normal regular firing. We have hitherto investigated the intracellular events during bursting activity in a single neuron. I would like to talk about our experiments on such cellular mechanisms of epileptogenic phenomena, especially intracellular events during seizure activity. I will also describe anticonvulsant effects of a herbal mixture,. TJ-960, which shows a different mechanism of action from pure chemical anticonvulsants; and finally I will give some hints for future therapy against epilepsy.

Keywords

Burst Activity Cellular Physiology Intracellular Free Calcium Kampo Medicine Herbal Mixture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Eiichi Sugaya
    • 1
    • 2
  • Aiko Sugaya
    • 3
  • Kagemasa Kajiwara
    • 1
    • 2
  • Tadashi Tsuda
    • 3
  • Noriyo Kubota
    • 3
  • Noriyuki Yuyama
    • 1
  • Masahiro Motoki
    • 3
  • Tamaki Takagi
    • 1
  • Hisaaki Takagi
    • 1
  • Tamiko Ookura
    • 2
  • Hideko Nagasawa
    • 2
  1. 1.Department of PhysiologyKanagawa Dental CollegeYokosukaJapan
  2. 2.Laboratory of Neurobiology Tsumura Institute for Oriental MedicineKeio University, School of MedicineTokyoJapan
  3. 3.Faculty of Pharmaceutical SciencesJosai UniversitySaitamaJapan

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