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Effect of MAK-4 and MAK-5 on Endothelial Cell and Soyabean Lipoxygenase-Induced LDL Oxidation

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Free Radicals in Diagnostic Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 366))

Abstract

Excessive free radical formation is the biochemical basis for oxidant injury to cells. Free radicals have been implicated in the pathogenesis of a wide variety of diseases. MAK-4 and MAK-5 are herbal antioxidant mixtures1,2. In this study, we investigated the antioxidant effect of MAK-4 and MAK-5 on endothelial cell (EC)- and soyabean lipoxygenase (SLP)-induced LDL oxidation and SLP-induced linoleic acid oxidation.

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References

  1. H.M. Sharma, A.N. Hanna, E.M. Kauffman, and H.A.I. Newman, Inhibition of human low density lipoprotein oxidation in vitro by Maharishi Ayur Veda herbal mixtures, Pharmacol. Biochem. Behav. 43:1175 (1992).

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  2. C. Dwivedi, H.M. Sharma, S. Dobrowski, and F.N. Engineer, Inhibitory effects of Maharishi-4 and Maharishi-5 on microsomal lipid peroxidation, Pharmacol. Biochem. Behav. 39:648 (1991).

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  3. L.E. Lantry, A.W. Fryczkowski, and R.E. Stephens, A human microvascular endothelial cell model of angiogenesis in diabetes, In Vitro Cell. Dev. Biol. 27A:164A (1991).

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Authors and Affiliations

  1. Department of Pathology College of Medicine, The Ohio State University, Columbus, OH, 43210, USA

    Hari M. Sharma, Atef N. Hanna, Lynda C. Titterington & Ralph E. Stephens

Authors
  1. Hari M. Sharma
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  2. Atef N. Hanna
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  3. Lynda C. Titterington
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  4. Ralph E. Stephens
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Editor information

Editors and Affiliations

  1. State University of New York at Buffalo, Buffalo, New York, USA

    Donald Armstrong

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© 1994 Springer Science+Business Media New York

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Sharma, H.M., Hanna, A.N., Titterington, L.C., Stephens, R.E. (1994). Effect of MAK-4 and MAK-5 on Endothelial Cell and Soyabean Lipoxygenase-Induced LDL Oxidation. In: Armstrong, D. (eds) Free Radicals in Diagnostic Medicine. Advances in Experimental Medicine and Biology, vol 366. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1833-4_46

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  • DOI: https://doi.org/10.1007/978-1-4615-1833-4_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5742-1

  • Online ISBN: 978-1-4615-1833-4

  • eBook Packages: Springer Book Archive

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