Vascular and Cellular Protein Changes Precede Hippocampal Pyramidal Cell Loss Following Global Ischemia in the Rat
Several recent studies have reported increased blood-brain barrier (BBB) permeability to large molecules such as immunoglobins and serum albumin following global ischemia.1 These studies have been qualitative, however, using immunohistochemical methods with descriptive results. Furthermore, no studies have assessed the BBB permeability of hemoglobin following global ischemia. This is especially relevant since hemoglobin has been reported to generate free radicals and be neurotoxic in vitro and in vivo.2 Free radicals, or reactive oxygen species, have been hypothesized to be a contributory factor in several neurodegenerative disorders, including ischemia.3
KeywordsPyramidal Cell Global Ischemia Adenylate Kinase Peptide Fraction Outlier Test
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