Involvement of Hydroxyl Radicals in Endotoxin-Evoked Shock

  • Daniel J. Brackett
  • Megan R. Lerner
  • Michael F. Wilson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 366)


There has been a myriad of publications recently evaluating the potential role of free radicals in the development and lethality of shock induced by endotoxin. Studies utilizing various types of compounds to interrupt the activity of free radicals or the injurious processes initiated by free radicals have not proven conclusive and the area remains controversial. This may be due to differences in the species of free radicals targeted by the inhibitory compounds selected and by the capacity of the compounds to effect intracellular free radical activity. Inhibitors of free radical activity that cross the cell membrane more effectively attenuate responses to endotoxin.1 The hydroxyl radical is the most toxic of the free radical species and has been implicated as having a role in endotoxin-induced pulmonary damage and lethality in a study utilizing dimethyl sulfoxide.2 Dimethyl sulfoxide (DMSO) is a hydroxyl radical scavenger that readily penetrates the cell membrane and therefore has the capacity to influence the actions of excessive intracellular hydroxyl radical generation. The studies described here were designed to exploit the properties of DMSO to evaluate the involvement of hydroxyl radical activity in hemodynamic, metabolic, and pathologic responses evoked by endotoxin.3


Central Venous Pressure Hydroxyl Radical Scavenger Circ Shock Hydroxyl Radical Activity Free Radical Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    K. McKechnie, B.L. Furman, and J.R. Parratt, Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin in conscious rats, Circ Shock 19:429 (1986).PubMedGoogle Scholar
  2. 2.
    R.E. Breen, R.S. Conneoo, and M.W. Harrison, The effect of dimethyl sulfoxide In endotoxin-induced pulmonary dysfunction: A biochemical and electron microscope study, Ann NY Acad Sci 411:324 (1983).PubMedCrossRefGoogle Scholar
  3. 3.
    D.J. Brackett, M.R. Lerner, and M.F. Wilson, Dimethyl sulfoxide antagonizes hypotensive, metabolic, and pathologic responses induced by endotoxin, Circ Shock 33:156 (1991).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Daniel J. Brackett
    • 1
  • Megan R. Lerner
    • 1
  • Michael F. Wilson
    • 2
  1. 1.Departments of Surgery and AnesthesiologyUniversity of Oklahoma Health Sciences Center and the Veterans Affairs Medical CenterOklahoma CityUSA
  2. 2.Department of MedicineState University of New York Millard Fillmore HospitalsBuffaloUSA

Personalised recommendations