The Potential of Gliclazide, a Sulphonylurea to Influence the Oxidative Processes within the Pathogenesis of Diabetic Vascular Disease
The major consequence of diabetes mellitus is that it predisposes to serious vascular disease which affects both the quality and quantity of life. The vascular disease affects both the small vessels (microangiopathy) and the large vessels (macroangiopathy)1. Specific diabetic microangiopathic changes are characterised by increased basement membrane thickening, increased capillary permeability and microthrombus formation. These changes are generalised, found throughout the vascular tree, having major clinical effects in the kidney, retina, peripheral nerve, myocardium and skin. Diabetic patients have a 25 fold increase in the risk of blindness, and diabetes is the major cause of renal failure in the UK and USA2.
KeywordsAldose Reductase Platelet Reactivity Arachidonic Acid Cascade Large Vessel Disease Thrombotic Tendency
Unable to display preview. Download preview PDF.
- (3).V.W. Monnier. Toward a Maillard theory of ageing. In Baynes J.W.; Monnier V.M. eds. The Malliard Reaction in ageing, diabetes and nutrition. New York; Alan R. Liss inc; 1–22 (1989)Google Scholar
- (4).M. Brownlee H. Vlassara and A. Cerami. The pathogenetic role of non-enzymatic glycosylation in diabetic complications. In Crabbe M.J.C. Ed. Diabetic complications; Scientific and clinical aspects. Edinburgh; Churchill Livingstone, 94–139 (1987)Google Scholar
- (7).P.H. Procter and E.S. Reynolds. Free radicals and disease in man. Physiol Chem Phys 16; 175–195 (1984)Google Scholar
- (11).A.F. Jones P.E. Jennings A. Wakefield J.W. Winkles J. Lunec and A.H. Barnett. The fluoresence of serum proteins in diabetes mellitus. Relationship to microangiopathy Diabetic Medicine 5; 547–551(1988)Google Scholar
- (13).S.P. Wolff. The potential role of oxidative stress in diabetes and its complications; novel implications for theory and therapy. In diabetic Complications; Scientific and clinical aspects. Crabbe M.J.C. (Ed) Churchill Livingstone 167–221 (1987)Google Scholar
- (14).D.G. Cogan Aldose Reductase and complications of diabetes. Annal Int Med 101; 82–91 (1984)Google Scholar
- (15).H.P. Misra and I. Fridovich. Superoxide radical and free radicals in clinical chemistry Ann Clin Biochem. 13: 393–398. (1979)Google Scholar
- (18).D.B. Campbell. P. Adrigenssens Y.W. Hopkins B. Gordon and J.R.B. Williams Pharmacokinetics and metabolism of gliclazide; a review in; Gliclazide and the Treatment of Diabetes (Proceedings Internatinal Symposium, London) eds. Keen et al. p. 71 (1979)Google Scholar
- (21).C.M. Florkowski M.R. Richardson C. Le Guen P.E. Jennings M.J. O’Donnell. A.F. Jones J. Lunec and A.H. Barnett Effect of gliclazide on thromboxane B2, parameters of haemostasis, fluorescent lgG and lipid peroxides in non-insulin dependent mellitus. Diabetes Research 9; 87–90 (1988)PubMedGoogle Scholar
- (23).Austs: Lipid peroxidation. In Greenwald R.A. (ed): Handbook of Methods for oxygen Free Radicals. Research, Boca Raton, FL, LRL, pp 203–207 (1987)Google Scholar