Involvement of Free Radical Mechanism in the Toxic Effects of Alcohol: Implications for Fetal Alcohol Syndrome

  • C. Guerri
  • C. Montoliu
  • J. Renau-Piqueras
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 366)


The role of free-radicals in alcohol-induced organ damage is still a matter of debate, in spite of decades of research. Moreover, during the last few years, great advances have been made in our understanding of the mechanisms of ethanol-induced enhancement of oxidative damage in liver and certain extrahepatic tissues. These advances have led to promising therapeutic approaches for the prevention of ethanol-induced oxidative stress. The present review focuses on the ethanol-induced production of pro-oxidant reactive species in different organs, an on the factors involved in ethanol metabolism that contribute to the generation of excess amounts of free radicals. Finally, the possible contribution of free radical generation to alcohol-induced fetal effects (fetal alcohol syndrome) are also discussed.


Lipid Peroxidation Alcoholic Liver Disease Free Radical Generation Chronic Ethanol Fetal Alcohol Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • C. Guerri
    • 1
  • C. Montoliu
    • 1
  • J. Renau-Piqueras
    • 2
  1. 1.Inst. Invest. Citológicas (FIB)Spain
  2. 2.Ctr. Invest. Hospital La FeValenciaSpain

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