Abstract
Tissue iron overload causes cell damage and organ dysfunction. The mechanisms of iron uptake by tissues and the probable biochemical pathways of iron-derived tissue injury will be reviewed. The iron-overload states are the initial clinical setting where the contribution of iron-catalyzed oxidative injury to the pathogenesis of a clinical disease has been appreciated. When viewed from the perspective of oxidative injury, the iron-overload syndromes also provide a model of tissue injury that is applicable to other disease states, including inflammation, ischemia-reperfusion injury, and anthracycline-induced cardiac toxicity. The goal of this chapter will be to provide a brief clinical overview of the iron-overload states, review the mechanisms of tissue iron uptake in normal and pathologic situations, the likely cellular targets and reactions of iron-catalyzed oxidative injury, and the clinical therapy of the iron-overload syndromes. The potential role of iron-catalyzed oxidative injury in the myocardial damage resulting from ischemia and reperfusion, and from anthracycline administration will also be discussed.
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Lesnefsky, E.J. (1994). Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury. In: Armstrong, D. (eds) Free Radicals in Diagnostic Medicine. Advances in Experimental Medicine and Biology, vol 366. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1833-4_10
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DOI: https://doi.org/10.1007/978-1-4615-1833-4_10
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