Skip to main content

Laboratory Empiricism, Clinical Design, and Social Value

The Rough Road toward Vaccine Development

  • Chapter
Book cover Vaccine Design

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

Vaccine development is inherently different from therapeutic drug development. Each step in vaccine development is influenced by the perceived value of the vaccine to be developed. That perception of value begins with the public who, ultimately, determine how important they consider the prevention of a given disease. Unfortunately, the public commonly undervalues the impact, and therefore value, of disease prevention in general. As a result, the full disease prevention potential of vaccines has yet to be realized. Smallpox has been eradicated by vaccine. Polio may soon be eradicated by vaccine. Measles, tetanus, diphtheria, and pertussis have been markedly reduced. But, considering the potential for the control or elimination of diseases with vaccine, we have only scratched the surface.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ada, G., 1993, HIV-towards Phase III trials for candidate vaccines, Nature 364:489–490.

    Article  PubMed  CAS  Google Scholar 

  • Blackwelder, W. C., Storsaeter, J., Olin, P., and Hallander, H. O., 1991, Acellular pertussis vaccines. Efficacy and evaluation of clinical case definitions, Am. J. Dis. Child. 145:1285–1289.

    PubMed  CAS  Google Scholar 

  • Carter, R., 1966, Breakthrough. The Saga of Jonas Salk, Trident Press, New York.

    Google Scholar 

  • Francis, D. P., Hadler, S. C., Thompson, S. E., Maynard, J. E., Ostrow, D. G., Altman, N., Braff, E. H., O’Malley, P., Hawkins, D., Judson, F. N., Penley, K., Nylund, T., Christie, G., Meyers, F., Moore, J. N., Jr., Gardner, A., Doto, I. L., Miller, J. H., Reynolds, G. H., Murphy, B. L., Schable, C. A., Clark, B. T., Curran, J. W., and Redeker, A. G., 1982, The prevention of hepatitis B with vaccine. Report of the CDC multi-center efficacy trial among homosexual men, Ann. Intern. Med. 97:362–366.

    PubMed  CAS  Google Scholar 

  • Maupas, P., Goudeau, A., Coursaset, P., and Druker, J., 1976, Immunisation against hepatitis B in man, Lancet 1:289–292.

    Google Scholar 

  • Purcell, R. H., Gerin, J. L., 1975, Hepatitis B subunit virus vaccine: A preliminary report of safety and efficacy tests in chimpanzees, Am. J. Med. Sci. 270:395–399.

    Article  PubMed  CAS  Google Scholar 

  • Redeker, A. G., Mosley, J. W., Gocke, D. J., McKee, A. P., and Pollack, W., 1975, Hepatitis B immune globulin as a prophylactic measure for spouses exposed to acute type B hepatitis, N. Engl. J. Med. 293:1055.

    Article  PubMed  CAS  Google Scholar 

  • Smith, J., 1990, Patenting the Sun. Polio and the Salk Vaccine, Morrow, New York.

    Google Scholar 

  • Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Oleszko, W. R., William, D. C., Sadovsky, R., Morrison, J. M., and Kellner, A., 1980, Hepatitis B vaccine. Demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States, N. Engl. J. Med. 303:833–841.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Francis, D.P. (1995). Laboratory Empiricism, Clinical Design, and Social Value. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1823-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5737-7

  • Online ISBN: 978-1-4615-1823-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics