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Design of Experimental Synthetic Peptide Immunogens for Prevention of HIV-1 and HTLV-I Retroviral Infections

  • Chapter
Vaccine Design

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

The potential for using synthetic peptides to serve as components of protective vaccines or as immunotherapeutics (see Chapter 38) is being explored for a variety of viral or bacterial pathogens. Peptide immunogens that elicit some level of protection in animal models or in clinical trials have been described for foot-and-mouth disease virus (Bittle et al., 1982), murine mammary tumor virus (Dion et al., 1990), Venezuelan equine encephalitis virus (Hunt et al., 1990), respiratory syncytial virus (Trudel et al., 1991), Semliki Forest virus (Snijders et al., 1992), Sendai virus (Kast et al., 1991), lymphocytic choriomeningitis virus (M. Schulz et al., 1991), group A streptococci (Bessen and Fischetti, 1990), and Plasmodium falciparum (Rodriguez et al., 1990; Etlinger et al., 1991).

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Authors and Affiliations

  1. Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland, 21702, USA

    Mary Kate Hart

  2. Department of Rheumatology and Immunology and the Duke Center for AIDS Research, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Thomas J. Palker & Barton F. Haynes

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  1. Mary Kate Hart
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  2. Thomas J. Palker
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  3. Barton F. Haynes
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  1. Genentech, Inc., South San Francisco, California, USA

    Michael F. Powell

  2. Vaxcel, Inc., Norcross, Georgia, USA

    Mark J. Newman

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Hart, M.K., Palker, T.J., Haynes, B.F. (1995). Design of Experimental Synthetic Peptide Immunogens for Prevention of HIV-1 and HTLV-I Retroviral Infections. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_37

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