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Vaccine Adjuvants Based on Gamma Inulin

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Vaccine Design

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 6))

Abstract

Vertebrates, and our particular concern the mammals, have obviously competed with microbes throughout their evolution and have tailor-made certain automatic defenses. Their leukocytes have evolved surface receptors specific for certain components of microbial cell walls such as β-glucan (Czop and Kay, 1991) and LPS (Lynn and Golenbock, 1992), ligation of which triggers particular cellular defenses. These are important in guarding against the targeted parasite. Several microbial components have been developed as vaccine adjuvants (Cox and Coulter, 1992), using the term in its original sense of “general helpers.”

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References

  • Arvieux, J., Yssel, H., and Colomb, M. G., 1988, Antigen-bound C3b and C4b enhance Ag-presenting cell function in activation of T-cell clones, Immunology 65:229–235.

    PubMed  CAS  Google Scholar 

  • Bitter-Suermann, D., and Burger, R., 1989, C3 deficiencies, Curr. Top. Microbiol. Immunol. 153:223–233.

    Article  Google Scholar 

  • Bloom, B. R., Salgame, P., and Diamond, B., 1992, Revisiting and revising suppressor T cells, Immunol. Today 13:131–136.

    Article  PubMed  CAS  Google Scholar 

  • Bokish, V. A., and Müller-Eberhard, H. J., 1970, Anaphylatoxin inactivator of human plasma: Its isolation and characterisation as a carboxypeptidase, J. Clin. Invest. 49:2427–2436.

    Article  Google Scholar 

  • British Pharmaceutical Codex, 1979, 11th ed., The Pharmaceutical Press, London.

    Google Scholar 

  • Chevis, R., 1990, Some effects of free radicals in parasite infections, Ph.D. thesis, Australian National University.

    Google Scholar 

  • Cooper, P. D., 1985, Complement and cancer: Activation of the alternative pathway as a theoretical base for immunotherapy, in: Advances in Immunology and Cancer Therapy, Vol. 1 (P. K. Ray, ed.), Springer-Verlag, Berlin, pp. 125–166.

    Chapter  Google Scholar 

  • Cooper, P. D., 1993, Solid phase activators of the alternative pathway of complement, in: Activators and Inhibitors of Complement (R. B. Sim, ed.), Kluwer Academic Publishers, Dordrecht, pp. 69–106.

    Chapter  Google Scholar 

  • Cooper, P. D., 1994, The selective induction of different immune responses by vaccine adjuvants, in: Vaccination Strategies to Control Infections (G. L. Ada, ed.), R.G. Landes Co., New York, pp. 125–157.

    Google Scholar 

  • Cooper, P. D., and Carter, M., 1986a, Anticomplementary action of polymorphic’ solubility forms’ of particulate inulin, Mol. Immunol. 23:895–901.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D., and Carter, M., 1986b, The anti-melanoma activity of inulin in mice, Mol. Immunol. 23:903–908.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D., and Sim, R. B., 1984, Substances that can trigger activation of the alternative pathway of complement have anti-melanoma activity in mice, Int. J. Cancer 33:686–687.

    Article  Google Scholar 

  • Cooper, P. D., and Steele, E. J., 1988, The adjuvanticity of gamma inulin, Immunol. Cell Biol. 66:345–352.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D., and Steele, E. J., 1991, Algammulin: A new vaccine adjuvant comprising gamma inulin particles containing alum, Vaccine 9:351–357.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D., McComb, C., and Steele, E. J., 1991a, The adjuvanticity of Algammulin, a new vaccine adjuvant, Vaccine 9:408–415.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D., Turner, R., and McGovern, J., 1991b, Algammulin (gamma inulin/alum hybrid adjuvant) has greater adjuvanticity than alum for hepatitis B surface antigen in mice, Immunol. Lett. 27:131–134.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D., Steele, E. J., McComb, C., McGovern, J., and Turner, R., 1993, Gamma inulin and Algammulin: Two new vaccine adjuvants, in: Vaccines 93. Modern Approaches to New Vaccines Including Prevention of AIDS (H. S. Ginsberg, F. Brown, R. M. Chanock, and R. A. Lerner, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 25–30.

    Google Scholar 

  • Cox, J. C., and Coulter, A. R., 1992, Advances in adjuvant technology and application, in: Animal Parasite Control Utilizing Biotechnology (W. K. Yong, ed.), CRC Press, Boca Raton, pp. 49–112.

    Google Scholar 

  • Craddock, P. R., Fehr, J., Dalmasso, A. P., Brigham, K. L., and Jacob, H. S., 1977, Hemodialysis leukopenia. Pulmonary vascular leukotaxis resulting from complement activation by dialyzer cellophane membranes, J. Clin. Invest. 59:879–888.

    Article  PubMed  CAS  Google Scholar 

  • Czop, J. K., 1986, Phagocytosis of particulate activators of the alternative complement pathway: Effects of fibronectin, Adv. Immunol. 38:361–398.

    Article  PubMed  CAS  Google Scholar 

  • Czop, J. K., and Kay, J., 1991, Isolation and characterization of beta-glucan receptors on human mononuclear phagocytes, J. Exp. Med. 173:1511–1520.

    Article  PubMed  CAS  Google Scholar 

  • Czop, J. K., Fearon, D. T., and Austen, K. F., 1978, Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes, Proc. Natl. Acad. Sci. USA 75:3831–3835.

    Article  PubMed  CAS  Google Scholar 

  • Czop, J. K., Valiant, N. M., and Janusz, M. J., 1989, Phagocytosis of particulate activators of the human alternative complement pathway through beta-glucan receptors, Prog. Clin. Biol. Res. 297:287–296.

    PubMed  CAS  Google Scholar 

  • Dinarello, C. A., 1987, Interleukins, tumour necrosis factors (cachectin) and interferons as endogenous pyrogens and mediators of fever, in: Lymphokines, Vol. 14 (E. Pick, ed.), Academic Press, New York, pp. 1–31.

    Google Scholar 

  • Erdei, A., Spaeth, E., Alsenz, J., Rüde, E., Schultz, T., Gergely, J., and Dierich, M. P., 1984, Role of C3b receptors in the enhancement of interleukin-2-dependent T-cell proliferation, Mol. Immunol. 21:1215–1221.

    Article  PubMed  CAS  Google Scholar 

  • Erdei, A., Bajtay, Z., Fabry, Z., Sim, R. B., and Gergely, J., 1988, Appearance of acceptor-bound C3b on HLA-DR positive macrophages and on stimulated U937 cells; inhibition of Fcγ receptors by the covalently fixed C3 fragments, Mol. Immunol. 25:295–303.

    Article  PubMed  CAS  Google Scholar 

  • Erdei, A., Fiist, G., and Gergely, J., 1991, The role of C3 in the immune response, Immunol. Today 12:332–337.

    Article  PubMed  CAS  Google Scholar 

  • Erdei, A., Köler, V., Schäfer, H., and Burger, R., 1992, Macrophage-bound C3 fragments as adhesion molecules modulate presentation of exogenous antigens, Immunobiology 185:314–326.

    Article  PubMed  CAS  Google Scholar 

  • Fearon, D. T., and Ahearn, J. M., 1990, Complement receptor type 1 (C3b/C4b receptor: CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor: CD21), Curr. Top. Microbiol. Immunol. 153:83–98.

    Article  PubMed  CAS  Google Scholar 

  • Feingold, D. S., and Avigad, G., 1956, Isolation of sucrose and other related Oligosaccharides from partial acid hydrolysate of inulin, Biochim. Biophys. Acta 22:196–197.

    Article  PubMed  CAS  Google Scholar 

  • Gergeley, J., Erdei, A., and Fabry, Z., 1984, Modulation of Fc receptor mediated functions by split products of C3, Mol. Immunol. 21:1205–1211.

    Article  Google Scholar 

  • Gilman, A. G., 1987, G proteins, transducers of receptor-generated signals, Annu. Rev. Biochem. 56:615–649.

    Article  PubMed  CAS  Google Scholar 

  • Götze, O., and Müller-Eberhard, H. J., 1971, The C3 activation system: An alternative pathway of complement activation, J. Exp. Med. 134:90–108.

    PubMed  Google Scholar 

  • Gray, D., and Skarvall, H., 1988, B cell memory is short-lived in the absence of antigen, Nature 336:70–72.

    Article  PubMed  CAS  Google Scholar 

  • Green, S., Dobrjansky, A., Chiasson, M. A., Carswell, E., Schwartz, M. K., and Old, L. J., 1977, C. parvum as the priming agent in the production of tumor necrosis factor in the mouse, J. Natl. Cancer Inst. 59:1519–1522.

    PubMed  CAS  Google Scholar 

  • Greenspan, N. S., and Cooper, L. J. N., 1992, Intermolecular cooperativity: A clue to why mice have IgG3? Immunol. Today 13:164–168.

    Article  PubMed  CAS  Google Scholar 

  • Griffin, F. M., 1977, Opsonization, in: Comprehensive Immunology, Vol. 5 (R. A. Good and S. B. Day, eds.), Plenum Press, New York, pp. 85–113.

    Google Scholar 

  • Hakim, R. M., 1986, Clinical sequelae of complement activation in hemodialysis, Clin. Nephrol. 26(Suppl. I):s9–s12.

    PubMed  CAS  Google Scholar 

  • Hakim, R. M., and Schaefer, A. I., 1985, Hemodialysis-associated platelet activation and thrombocytopenia, Am. J. Med. 78:575–580.

    Article  PubMed  CAS  Google Scholar 

  • Hakim, R. M., Breillatt, J., Lazarus, J. M., and Port, F. K., 1984, Complement activation and hypersensitivity reactions to dialysis membranes, N. Engl. J. Med. 311:878–882.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, T. A., and Adams, D. O., 1987, Molecular mechanisms of signal transduction in macrophages, Immunol. Today 8:151–158.

    Article  CAS  Google Scholar 

  • Hebell, T., Ahearn, J. M., and Fearon, D. T., 1991, Suppression of the immune response by a soluble complement receptor of B lymphocytes, Science 254:102–105.

    Article  PubMed  CAS  Google Scholar 

  • Heyman, B., Wiersma, E. J., and Kinoshita, T., 1990, In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody, J. Exp. Med. 172:665–668.

    Article  PubMed  CAS  Google Scholar 

  • Ivanovich, P., Chenoweth, D. E., Schmidt, R., Klinkman, H., Boxer, L. A., Jacob, H. S., and Hammerschmidt, D. E., 1983, Symptoms and activation of granulocytes and complement with two dialysis membranes, Kidney Int. 24:758–763.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, E., Eskeland, T., and Bertheussen, K., 1984, Phagocytosis by human monocytes of particles activating the alternative pathway of complement, Scand. J. Immunol. 19:31–39.

    Article  PubMed  CAS  Google Scholar 

  • Jones, G. L., Spencer, L., Lord, R., Mollard, R., Pye, D., and Saul, A., 1990, Peptide vaccines derived from a malarial surface antigen: Effects of dose and adjuvants on immunogenicity, Immunol. Lett. 24:253–260.

    Article  PubMed  CAS  Google Scholar 

  • Karagouni, E. E., and Hadjipetrou-Kourounakis, L., 1990, Regulation of isotype immunoglobulin production by adjuvants in vivo, Scand. J. Immunol. 31:745–754.

    Article  PubMed  CAS  Google Scholar 

  • Kenney, J. S., Hughes, B. W., Masada, M. P., and Allison, A. C., 1989, Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies, J. Immunol. Methods 121:157–166.

    Article  PubMed  CAS  Google Scholar 

  • Kensil, C. R., Patel, U., Lennick, M., and Marciani, D., 1991, Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex, J. Immunol. 146:431–437.

    PubMed  CAS  Google Scholar 

  • Klaus, G. G. B., and Humphrey, J. H., 1986, Are-evaluation of the role of C3 in B-cell activation, Immunol. Today 7:163–165.

    Article  CAS  Google Scholar 

  • Knudsen, F., Nielsen, A. H., Pedersen, J. O., Grunnet, N., and Jersild, C., 1985, Adult respiratory distress-like syndrome during hemodialysis: Relationship between activation of complement, leukopenia, and release of granulocyte elastase, Int. J. Artif. Organs 8:187–194.

    PubMed  CAS  Google Scholar 

  • Lachmann, P. J., 1979, Complement, in: The Antigens, Vol. 5 (M. Sela, ed.), Academic Press, New York, pp. 283–303.

    Google Scholar 

  • Lambris, J. D., 1988, The multifunctional role of C3, the third component of complement, Immunol Today 9:387–393.

    Article  PubMed  CAS  Google Scholar 

  • Lambris, J. D., Becherer, J. D., Servis, C., and Alsenz, J., 1993, Use of synthetic peptides in exploring and modifying complement reactivities, in: Activators and Inhibitors of Complement (R. B. Sim, ed.), Kluwer Academic Publishers, Dordrecht, pp. 201–232.

    Chapter  Google Scholar 

  • Lynn, W. A., and Golenbock, D. T., 1992, Lipopolysaccharide antagonists, Immunol Today 13:271–276.

    Article  PubMed  CAS  Google Scholar 

  • McAleer, M. A., and Sim, R. B., 1993, The complement system, in: Activators and Inhibitors of Complement (R. B. Sim, ed.), Kluwer Academic Publishers, Dordrecht, pp. 1–15.

    Chapter  Google Scholar 

  • McDonald, E. J., 1946, The polyfructosans and difructose anhydrides, Adv. Carbohydr. Chem. 2:253–277.

    Article  CAS  Google Scholar 

  • Marchessault, R. H., Bleha, T., Deslandes, Y., and Revol, J. F., 1980, Conformation and crystalline structure of (2→1)-β-D-fructofuranan(inulin), Can. J. Chem. 58:2415–2421.

    Article  CAS  Google Scholar 

  • Melchers, F., Erdei, A., Schultz, T., and Dierich, M. P., 1985, Growth control of activated, synchronized murine B cells by the C3d fragment of human complement, Nature 317:264–267.

    Article  PubMed  CAS  Google Scholar 

  • Mosmann, T. R., and Coffman, R. L., 1989, Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties, Annu. Rev. Immunol. 7:145–173.

    Article  PubMed  CAS  Google Scholar 

  • Müller-Eberhard, H. J., 1981, The human complement protein C3: Its unusual functional and structural versatility in host defense and inflammation, in: Advances in Immunopathology (W. O. Weigle, ed.), Symp. Specialists Inc., Miami, pp. 141–160.

    Google Scholar 

  • Müller-Eberhard, H. J., 1988, Molecular organization and function of the complement system, Annu. Rev. Biochem. 57:321–347.

    Article  PubMed  Google Scholar 

  • Müller-Eberhard, H. J., and Schreiber, R. D., 1980, Molecular biology and chemistry of the alternative pathway of complement, Adv. Immunol. 29:1–55.

    Article  PubMed  Google Scholar 

  • Nissenson, A. R., Rice, L. E., Potter, E. V., et al., 1979, Variations in serum complement following inulin infusion in man, Nephron 23:218–222.

    Article  PubMed  CAS  Google Scholar 

  • Palmer, D. G., Cooper, P. D., Carnegie, P. R., Wallace, H., Deol, H. S., Thompson, R. C. A., and Dunsmore, T., 1990, A new Polysaccharide adjuvant (Algammulin) useful for the improvement of cell-mediated immune response in sheep. Aust. Soc. Parasitol Abstr., Fremantle, p. 51.

    Google Scholar 

  • Phelps, C. F., 1965, The physical properties of inulin solutions, Biochem. J. 95:41–47.

    PubMed  CAS  Google Scholar 

  • Pollock, C. J., Hall, M. A., and Roberts, D. P., 1979, Structural analysis of fructose polymers by gas-liquid chromatography and gel filtration, J. Chromatogr. 171:411–415.

    Article  CAS  Google Scholar 

  • Romagnani, S., 1992, Induction of Th1 and Th2 responses: A key role for the ‘natural’ immune response? Immunol. Today 13:379–381.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, H., and Law, S. K. A., 1990, The leukocyte cell surface receptors for the iC3b product of complement, Curr. Top. Microbiol. Immunol. 153:99–122.

    Article  PubMed  CAS  Google Scholar 

  • Ross, G. D., and Medof, M. E., 1985, Membrane complement receptors specific for bound fragments of C3, Adv. Immunol. 37:211–261.

    Google Scholar 

  • Saul, A., Lord, R., Jones, G. L., and Spencer, L., 1992, Protective immunization with invariant peptides of the Plasmodium falciparum antigen MSA2, J. Immunol. 148:208–211.

    PubMed  CAS  Google Scholar 

  • Stewart-Tull, D. E. S., 1989, Recommendations for the assessment of adjuvants (immunopotentiators), in: Immunological Adjuvants and Vaccines (G. Gregoriadis, A. C. Allison, and G. Poste, eds.), NATO ASI Series A: Life Sciences, Vol. 179, Plenum Press, New York, pp. 213–226.

    Chapter  Google Scholar 

  • Thyphronitis, G., Kinoshita, T., Inoue, K., Schweinle, J. E., Tsokos, G. C., Metcalf, E. S., Finkelman, F. D., and Balow, J. E., 1991, Modulation of mouse complement receptors 1 and 2 suppresses antibody responses in vivo, J. Immunol. 147:224–230.

    PubMed  CAS  Google Scholar 

  • Van Nest, G. A., Steimer, K. S., Haigwood, N. L., Burke, R. L., and Ott, G., 1992, Advanced adjuvant formulation for use with recombinant subunit vaccines, in: Vaccines 92. Modern Approaches to New Vaccines Including Prevention of AIDS (F. Brown, R. M. Chanock, H. S. Ginsberg, and R. A. Lerner, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 57–62.

    Google Scholar 

  • Verroust, P. J., Wilson, C. B., and Dixon, F. J., 1974, Lack of nephritogenicity of systemic activation of the alternative complement pathway, Kidney Int. 6:157–169.

    Article  PubMed  CAS  Google Scholar 

  • Wiersma, E. J., Kinoshita, T., and Heyman, B., 1991, Inhibition of immunological memory and T-independent humoral responses by monoclonal antibodies specific for murine complement receptors, Eur. J. Immunol. 21:2501–2506.

    Article  PubMed  CAS  Google Scholar 

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  1. Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia

    Peter D. Cooper

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  1. Peter D. Cooper
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  1. Genentech, Inc., South San Francisco, California, USA

    Michael F. Powell

  2. Vaxcel, Inc., Norcross, Georgia, USA

    Mark J. Newman

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Cooper, P.D. (1995). Vaccine Adjuvants Based on Gamma Inulin. In: Powell, M.F., Newman, M.J. (eds) Vaccine Design. Pharmaceutical Biotechnology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1823-5_24

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  • DOI: https://doi.org/10.1007/978-1-4615-1823-5_24

  • Publisher Name: Springer, Boston, MA

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