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Chemical inhibitors of cyclin-dependent kinases

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk’s), constituted of at least two subunits, a catalytic subunit (cdkl-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk’s is responsible for transition through the different phases of the cell cycle. Major abnormalities of cdk’s expression and regulation have been described in human tumours. Enzymatic screening is starting to uncover chemical inhibitors of cdk’s with anti-mitotic activities. This review summarizes our knowledge of these first inhibitors, their mechanism of action, their effects on the cell cycle, and discusses the potential of such type of inhibitors as anti-tumour agents.

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References

  1. Murray, A. and Hunt, T. (1993) The Cell Cycle. An Introduction. W.H. Freeman and CO, New York, pp. 1–251.

    Google Scholar 

  2. Glover, D., Hall, A. and Hastie, N. (Editors) (1994). J. Cell Sci. supplement 18, pp. 1–135.

    Google Scholar 

  3. Hunt, T. and Sherr, C. (Editors) (1994) Curr. Opinion in Cell Biol. 6, 833–882.

    Google Scholar 

  4. Nigg, E.A. (Editor) (1994) Seminars Dev. Biol. 5, 131–198.

    Google Scholar 

  5. Morgan, D.O. (1995) Nature. 374, 131–134

    Article  PubMed  CAS  Google Scholar 

  6. Meijer, L., Guidet, S. and Tung, H.Y.L. (Editors) (1995) Progress in Cell Cycle Research, Vol. 1, Plenum Press USA.

    Google Scholar 

  7. Van den Heuvel, S. and Harlow, E.E. (1993) Science 262, 2050–2054.

    Article  PubMed  Google Scholar 

  8. Meyerson, M., Enders, G.H., Wu, C.L., Su, L.K., Gorka, C., Nelson, C., Harlow, E. and Tsai, L.H. (1992) EMBO J. 11, 2909–2917.

    PubMed  CAS  Google Scholar 

  9. Hartwell, L. H. and Kastan, M.B. (1994). Science 266, 1821–1828.

    Article  PubMed  CAS  Google Scholar 

  10. Murray, A.W. (1992) Nature 359, 599–604.

    Article  PubMed  CAS  Google Scholar 

  11. Murray, A. (1994) Curr. Opinion Cell Biol. 6, 872–876.

    Article  PubMed  CAS  Google Scholar 

  12. Hunter, T. and Pines, J. (1994) Cell 79, 573–582.

    Article  PubMed  CAS  Google Scholar 

  13. De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O. and Kim, S.H. (1993) Nature 363, 595–602.

    Article  PubMed  Google Scholar 

  14. Ducommun, B., Brambilla, P., Felix, M.A., Franza, B.R.J., Karsenti, E. and Draetta, G. (1991) EMBO J. 10, 331–3319.

    Google Scholar 

  15. Gould, K.L., Moreno, S., Owen, D.J., Sazer, S. and Nurse, P. (1991) EMBO J. 10, 3297–3309.

    PubMed  CAS  Google Scholar 

  16. Kobayashi, H., Stewart, E., Poon, R., Adamczewski, J.P., Gannon, J. and Hunt, T. (1992) Mol. Biol. Cell 3, 1279–1294.

    PubMed  CAS  Google Scholar 

  17. Lees, E.M. and Harlow, E. (1993) Molecul. Cellul. Biol. 13, 1194–1201.

    CAS  Google Scholar 

  18. Endicott, J.A., Nurse, P. and Johnson, L.N. (1994) Protein Engineering 7, 243–253.

    Article  PubMed  CAS  Google Scholar 

  19. Nigg, E.A. (1993) Trends in Cell Biol. 3, 296–301.

    Article  CAS  Google Scholar 

  20. Zhang, J., Sanchez, R.J., Wang, S., Guarnaccia, C., Tossi, A., Zahariev, S. and Pongor, S. (1994) Arch. Biochem. Biophys. 315, 415–424.

    Article  PubMed  CAS  Google Scholar 

  21. Solomon, M.J. (1994). Trends in Biochem. Sci. 19, 496–500.

    Article  CAS  Google Scholar 

  22. Ducommun, B., Brambilla, P. and Draetta, G. (1991). Molecul. Cellul. Biol. 11, 6177–6184.

    CAS  Google Scholar 

  23. Desai, D., Wessling, H.C., Fisher, R.P. and Morgan, D.O. (1995) Molecul Cellul. Biol. 15, 345–350.

    CAS  Google Scholar 

  24. Azzi, L., Meijer, L., Reed, S.I., Pidikiti, R. and Tung, H.Y.L. (1992) Eur. J. Biochem. 203, 353–360.

    Article  PubMed  CAS  Google Scholar 

  25. Richardson, H.E., Stueland, C.S., Thomas, J. and Reed, S.I. (1990) Genes and Development 4, 1332–1344.

    Article  PubMed  CAS  Google Scholar 

  26. Parge, H.E., Arvai, A.S., Murtadi, D.J., Reed, S.I. and Tainer, J.A. (1993) Science 262, 387–395.

    Article  PubMed  CAS  Google Scholar 

  27. Kusubata, M., Tokui, T., Matsuoka, Y., Okumura, E., Tachibana, K., Hisanaga, S., Kishimoto, T., Yasuda, H., Kamijo, M., Ohba, Y.Y., Tsujimura, K., Yatani, R. and Inagaki, M. (1992) J. Biol. Chem. 267, 20937–20942.

    PubMed  CAS  Google Scholar 

  28. Azzi, L., Meijer, L., Ostvold, A.C., Lew, J. and Wang, J.H. (1994) J. Biol. Chem. 269, 13279–13288.

    PubMed  CAS  Google Scholar 

  29. Galaktionov, K. and Beach, D. (1991) Cell 67, 1181–1194.

    Article  PubMed  CAS  Google Scholar 

  30. Zheng, X.F. and Ruderman, J.V. (1993) Cell 75, 155–164.

    PubMed  CAS  Google Scholar 

  31. Peter, M. and Herskowitz, I. (1994) Cell 79, 181–184.

    Article  PubMed  CAS  Google Scholar 

  32. Gu, Y., Turck, C.W. and Morgan, D.O. (1993) Nature 366, 707–710.

    Article  PubMed  CAS  Google Scholar 

  33. Serrano, M., Hannon, G.J. and Beach, D. (1993) Nature 366, 704–707.

    Article  PubMed  CAS  Google Scholar 

  34. Hannon, G.J. and Beach, D. (1994) Nature 371, 257–261.

    Article  PubMed  CAS  Google Scholar 

  35. Guan, K.L., Jenkins, C.W., Li, Y., Nichols, M.A., Wu, X., O’Keefe, C.L., Matera, A.G. and Xiong, Y. (1994) Genes & Dev. 8, 2939–2952.

    Article  CAS  Google Scholar 

  36. El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, E., Kinzler, K.W. and Vogelstein, B. (1993) Cell 75, 817–825.

    Article  PubMed  CAS  Google Scholar 

  37. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) Cell 75, 805–816.

    Article  PubMed  CAS  Google Scholar 

  38. Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1994) Exp. Cell Res. 211, 90–98.

    Article  PubMed  CAS  Google Scholar 

  39. Polyak, K., Lee, M.H., Erdjument-Bromage, H., Koff, A., Roberts, J.M., Tempst, P. and Massagué, J. (1994) Cell 78, 59–66.

    Article  PubMed  CAS  Google Scholar 

  40. Toyoshima, H. and Hunter, T. (1994) Cell 78, 67–74.

    Article  PubMed  CAS  Google Scholar 

  41. Nakanishi, M., Robetorye, R.S., Adami, G.R., Pereira-Smith, O.M. and Smith, J.R. (1995). EMBO J. 14, 555–563.

    PubMed  CAS  Google Scholar 

  42. Glotzer, M., Murray, A.W. and Kirschner, M.W. (1991) Nature 349, 132–138.

    Article  PubMed  CAS  Google Scholar 

  43. Hershko, A., Ganoth, D., Pehrson, J., Palazzo, R.E. and Cohen, L.H. (1991) J. Biol. Chem. 266, 16376–16379.

    PubMed  CAS  Google Scholar 

  44. Hershko, A., Ganoth, D., Sudakin, V., Dahan, A., Cohen, L.H., Luca, F.C., Ruderman, J.V. and Eytan, E. (1994) J. Biol. Chem. 269, 4940–4946.

    PubMed  CAS  Google Scholar 

  45. King, R.W., Jackson, P.K. and Kirschner, M.W. (1994) Cell 79, 563–571.

    Article  PubMed  CAS  Google Scholar 

  46. Murray, A.W., Solomon, M.J. and Kirschner, M.W. (1989) Nature 339, 280–286.

    Article  PubMed  CAS  Google Scholar 

  47. Luca, F.C. and Ruderman, J.V. (1989) J. Cell Biol. 109, 1895–1909.

    Article  PubMed  CAS  Google Scholar 

  48. Luca, F.C., Shibuya, E.K., Dorhman, C.E. and Ruderman, J.V. (1991) EMBO J. 10, 4311–4320.

    PubMed  CAS  Google Scholar 

  49. Lorca, T., Devault, A., Colas, P., van Loon, A., Fesquet, D., Lazaro, J.B. and Dorée, M. (1992) FEBS Lett. 306, 90–93.

    Article  PubMed  CAS  Google Scholar 

  50. Holloway, S.L., Glotzer, M., King, R.W. and Murray, A.W. (1993) Cell 73, 1393–1402.

    Article  PubMed  CAS  Google Scholar 

  51. Ookata, K., Hisanaga, S.I., Okano, T., Tachibana, K. and Kishimoto, T. (1992) EMBO J. 11, 1763–1772.

    PubMed  CAS  Google Scholar 

  52. Pines, J. and Hunter, T. (1994) EMBO J. 13, 3772–3781.

    PubMed  CAS  Google Scholar 

  53. Ookata, K., Hisanaga, S.I., Okumura, E. and Kishimoto, T. (1993) J. Cell Sci. 105, 873–881.

    PubMed  CAS  Google Scholar 

  54. Fellous, A., Kubelka, M., Thibier, C., Taieb, F., Haccard, O. and Jessus, C. (1994) Int. J. Dev. Biol. 38, 651–659.

    PubMed  CAS  Google Scholar 

  55. Rialet, V. and Meijer, L. (1991) Anticancer Res. 11, 1581–1590.

    PubMed  CAS  Google Scholar 

  56. Omura, S., Iwai, Y., Hirao, A., Nakagawa, A., Awaya, J., Tsuchiya, H., Takahashi, Y. and Masuma, R. (1977) J. Antibiot. 30, 275–281.

    Article  PubMed  CAS  Google Scholar 

  57. Gadbois, D.M., Hamaguchi, J.R., Swank, R.A. and Bradbury, E.M. (1992) Biochem. Biophys. Res. Comm. 184, 80–85.

    Article  PubMed  CAS  Google Scholar 

  58. Abe, K., Yoshida, M., Usui, T., Horinouchi, S. and Beppu, T. (1991) Exp. Cell Res. 192, 122–127.

    Article  PubMed  CAS  Google Scholar 

  59. Crissman, H.A., Gadbois, D.M., Tobey, R.A. and Bradbury, E.M. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7580–7584.

    Article  PubMed  CAS  Google Scholar 

  60. Bruno, S., Ardelt, B., Skierski, J.S., Traganos, F. and Darzynkiewicz, Z. (1992) Cancer Res. 52, 470–473.

    PubMed  CAS  Google Scholar 

  61. Gadbois, D.M., Crissman, H.A., Tobey, R.A. Bradbury, E.M. (1992) Proc. Natl. Acad. Sci. USA 89, 8626–8630.

    Article  PubMed  CAS  Google Scholar 

  62. Kiriyama, N., Nitta, K., Sakaguchi, Y., Taguchi, Y. and Yamamoto, Y. (1977) Chem. Pharm. Bull. 25, 2593–2601.

    Article  CAS  Google Scholar 

  63. Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Suzuki-Takahashi, I., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y., Yasuda, H., Ohba, Y., Nishimura, S., Tanaka, N. and Okuyama, A. (1993) Oncogene 8, 2425–2432.

    PubMed  CAS  Google Scholar 

  64. Someya, A., Tanaka, N., and Okuyama, A. (1994) Biochem. Biophys. Res. Commun. 198, 536–545.

    Article  PubMed  CAS  Google Scholar 

  65. Kitagawa, M., Higashi, H., Suzuki-Takahashi, I., Okabe, T., Ogino, H., Taya, Y., Nishimura, S. and Okuyama, A. (1994) Oncogene 9, 2549–2557.

    PubMed  CAS  Google Scholar 

  66. Th’ng, J.P.H., Wright, P.S., Hamaguchi, J., Lee, M.G., Norbury, C.J., Nurse, P. and Bradbury, E.M. (1990) Cell 63, 313–324.

    Article  CAS  Google Scholar 

  67. Kaur, G., Stetler-Stevenson, M., Sebers, S., Worland, P., Sedlacek, H., Myers, C., Czech, J., Naik, R. ans Sausville, E. (1992) J. Natl. Cancer Inst. 84, 1736–1740.

    Article  PubMed  CAS  Google Scholar 

  68. Losiewiecz, M.D., Carlson, B.A., Kaur, G., Sausville, E.A. and Worland, P.J. (1994) Biochem. Biophys. Res. Commun. 201, 589–595.

    Article  Google Scholar 

  69. Worland, P.J., Kaur, G., Stetler-Stevenson, M., Sebers, S., Sartor, O. and Sausville, E.A. (1993) Biochem. Pharmacol. 46, 1831–1840.

    Article  PubMed  CAS  Google Scholar 

  70. Rebhun, L.I., White, D., Sander, G. and Ivy, N. (1973) Exp. Cell Res. 77, 312–318.

    Article  PubMed  CAS  Google Scholar 

  71. Meijer L. and Pondaven P. (1988) Exp. Cell Res. 174, 116–129.

    Article  PubMed  CAS  Google Scholar 

  72. Néant, I. and Guerrier, P. (1988) Exp. Cell Res. 176, 68–79.

    Article  PubMed  Google Scholar 

  73. Vesely, J., Havlicek, L., Strnad, M., Blow, J. J., Donella-Deana, A., Pinna, L., Letham, D.S., Kato, J.Y., Détivaud, L., Leclerc, S. and Meijer, L. (1994) Eur. J Biochem. 224, 771–786.

    Article  PubMed  CAS  Google Scholar 

  74. Parker, C.W., Entsch, B. and Letham, D.S. (1986) Phytochemistry 25, 303–310.

    Article  CAS  Google Scholar 

  75. Schulze-Gahmen, U., Brandsen, J., Heather, D.J., Morgan, D.O., Meijer, L., Vesely, J. and Kim, S.H. (1995) Proteins, in press.

    Google Scholar 

  76. Abraham, R.T., Acquarone, M., Andersen, A., Asensi, A., Bellé, R., Berger, F., Bergounioux, C., Brunn, G., Buquet-Fagot, C., Fagot, D., Glab, N., Goudeau, H., Goudeau, M., Guerrier, P., Houghton, P.J., Hendriks, H., Kloareg, B., Lippai, M., Marie, D., Maro, B., Meijer, L., Mester, J., Mulner-Lorillon, O., Poulet, S.A., Schierenberg, E., Schutte, B., Vaulot, D. and Verlhac, M.H. (1995) Biology of the Cell, 83, 105–120.

    Article  PubMed  CAS  Google Scholar 

  77. Glab, N., Labidi, H., Qin, L.-X., Trehin, C., Bergounioux, C. and Meijer, L. (1994) FEBS Lett. 353, 207–214.

    Article  PubMed  CAS  Google Scholar 

  78. Larsen, A.K. (1993) Cancer Chemother. Pharmacol. 32, 96–98.

    Article  PubMed  CAS  Google Scholar 

  79. Mahoney, C.W., Azzi, A. and Huang, K.P. (1990). J. Biol. Chem. 265, 5424–5428.

    PubMed  CAS  Google Scholar 

  80. Budman, D.R. (1992) in The Chemotherapy Source Book (Perry, M.C., ed.), chapter 27, pp. 439–496, Williams & Wilkins, Baltimore, USA.

    Google Scholar 

  81. Bojanowski, K., Nishio, K., Fukuda, M., Larsen, A.K. and Saijo, N. (1994) Biochem. Biophys. Res. Commun. 203, 1574–1580.

    Article  PubMed  CAS  Google Scholar 

  82. Motokura, T. and Arnold, A. (1993) Biochim. Biophys. Acta 1155, 63–78.

    PubMed  CAS  Google Scholar 

  83. Peters, G. (1994) J. Cell Sci. suppl. 18, 89–96.

    PubMed  CAS  Google Scholar 

  84. Jiang, W., Zhang, Y.J., Kahn, S.M., Hollstein, M.C., Santella, R.M., Lu, S.H., Harris, C.C., Montesano, R. and Weinstein, I.B. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 9026–9030.

    Article  PubMed  CAS  Google Scholar 

  85. Raynaud, S.D., Bekri, S., Leroux, D., Grosgeorge, J., Klein, B., Bastard, C., Gaudray, P. and Simon, M.P. (1993) Genes, Chromos, and Cancer 8, 80–87.

    Article  CAS  Google Scholar 

  86. Wu, L., Williams, R.T., Carbonaro-Hall, D.A., Liu, L., Tolo, V.T. and Hall, F.L. (1993) Int. J. Oncology 3, 859–867.

    CAS  Google Scholar 

  87. Zhang, Y.J., Jiang, W., Chen, C.J., Lee, C.S., Kahn, S.M., Santella, R.M. and Weinstein, I.B. (1993) Biochem. Biophys. Res. Comm. 196, 1010–1016.

    Article  PubMed  CAS  Google Scholar 

  88. Bartkova, J., Lukas, J., Muller, H., Lutzhoft, D., Strauss, M. and Bartek, J. (1994) Int. J. Cancer 57, 353–361.

    Article  PubMed  CAS  Google Scholar 

  89. Gillett, C., Fantl, V., Smith, R., Fisher, C., Bartek, J., Dickson, C., Barnes, D. and Peters, G. (1994) Cancer Res. 54, 1812–1817.

    PubMed  CAS  Google Scholar 

  90. Gong, J.P., Traganos, F. and Darzynkiewicz, Z. (1994) Cancer Res. 54, 3136–3139.

    PubMed  CAS  Google Scholar 

  91. Jares, P., Fernandez, P.L., Campo, E., Nadal, A., Bosch, F., Aiza, G., Nayach, I., Traserra, J. and Cardesa, A. (1994) Cancer Res. 54, 4813–4817.

    PubMed  CAS  Google Scholar 

  92. Keyomarsi, K., O’Leary, N., Molnar, G., Lees, E., Fingert, H.J. and Pardee, A.B. (1994) Cancer Res. 54, 380–385.

    PubMed  CAS  Google Scholar 

  93. Nishida, N., Fukuda, Y., Komeda, T., Kita, R., Sando, T., Furukawa, M., Amenomori, M., Shibagaki, I., Nakao, K., Ikenaga, M. and Ishizaki, K. (1994) Cancer Res. 54, 3107–3110.

    PubMed  CAS  Google Scholar 

  94. Schauer, I.E., Siriwardana, S., Langan, T.A. and Sclafani, R.A. (1994) Proc. Natl. Acad. Sci. USA 91, 7827–7831.

    Article  PubMed  CAS  Google Scholar 

  95. Yasui, W., Ayhan, A., Kitadai, Nishimura, K., Yokozaki, H. and Tahara, E. (1993) Int. J. Cancer 53, 36–41.

    Article  PubMed  CAS  Google Scholar 

  96. Reifenberger, G., Reifenberger, J., Ichimura, K., Meltzer, P.S. and Collins, V.P. (1994) Cancer Res. 54, 4299–4303.

    PubMed  CAS  Google Scholar 

  97. Hinds, P.W., Dowdy, S.F., Eaton, E.N., Arnold, A. and Weinberg, R.A. (1994) Proc. Natl. Acad. Sci. USA 91, 709–713.

    Article  PubMed  CAS  Google Scholar 

  98. Musgrove, E.A., Lee, C.S.L., Buckley, M.F. and Sutherland, R.L. (1994) Proc. Natl. Acad. Sci. USA 91, 8022–8026.

    Article  PubMed  CAS  Google Scholar 

  99. Wang, T.C., Cardiff, R.D., Zukerberg, L., Lees, E., Arnold, A. and Schmidt, E.V. (1994) Nature 369, 669–671.

    Article  PubMed  CAS  Google Scholar 

  100. Wang, J., Chenivesse, X., Henglein, B. and Bréchot, C. (1990) Nature 343, 555–557.

    Article  PubMed  CAS  Google Scholar 

  101. Keyomarsi, K. and Pardee, A.B. (1993) Proc. Natl. Acad. Sci. USA 90, 1112–1116.

    Article  PubMed  CAS  Google Scholar 

  102. Cheng, J.Q., Jhanwar, S.C., Klein, W.M., Bell, D.W., Lee, W.C., Altomare, D.A., Nobori, T., Olopade, O.I., Buckler, A.J. and Testa, J.R. (1994) Cancer Res. 54, 5547–5551.

    PubMed  CAS  Google Scholar 

  103. Duro, D., Flexor, M.A., Bernard, O., d’Agay, M.F., Berger, R. and Larsen, C.J. (1994) C.R. Acad. Sci. Paris 317, 913–919.

    PubMed  CAS  Google Scholar 

  104. Hébert, J., Cayuela, J.M., Berkeley, J. and Sigaux, F. (1994) Blood 84, 4038–4044.

    PubMed  Google Scholar 

  105. Hussussian, C.J., Struewing, J.P., Goldstein, A.M., Higgins, P.A.T., Ally, D.S., Sheahan, M.D., Clark, W.H., Tucker, M.A. and Dracopoli, N.C. (1994) Nature Genet. 8, 15–21.

    Article  PubMed  CAS  Google Scholar 

  106. Walker, D.G., Duan, W., Popovic, E.A., Kaye, A.H., Tomlinson, F.H. and Levin, M. (1994) Cancer Res. 55, 20–23.

    Google Scholar 

  107. Cayuela, J.M., Hébert, J. and Sigaux, F. (1995) Blood 85, 854.

    PubMed  CAS  Google Scholar 

  108. Igaki, H., Sasaki, H., Kishi, T., Sakamoto, H., Tachimori, Y., Kato, H., Watanabe, H., Sugimura, T. and Terada, M. (1994) Biochem. Biophys. Res. Comm. 203, 1090–1095.

    Article  PubMed  CAS  Google Scholar 

  109. Nobori, T., Miura, K., Wu, D.J., Lois, A., Takabayashi, K. and Carson, D.A. (1994) Nature 368, 753–756.

    Article  PubMed  CAS  Google Scholar 

  110. Okamoto, K. Demetrik, D.J., Spillare, E.A., Hagiwara, K., Hussain, S.P., Bennett, W.P., Forrester, K., Gerwin, B., Serrano, M., Beach, D. and Harris, C.C. (1994) Proc. Natl. Acad. Sci. USA. 91, 11045–11049.

    Article  PubMed  CAS  Google Scholar 

  111. Gibbs, J.B. and Oliff, A. (1994) Cell 79, 193–198.

    Article  PubMed  CAS  Google Scholar 

  112. Levitzki, A. (1994) Eur. J. Biochem. 226, 1–13.

    Article  PubMed  CAS  Google Scholar 

  113. Powis, G. (1994) Pharmac. Ther. 62, 57–95.

    Article  CAS  Google Scholar 

  114. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) Cell 75, 805–816.

    Article  PubMed  CAS  Google Scholar 

  115. Xiong, Y., Harmon, G.J., Zhang, H., Casso, D., Kobayashi, R. and Beach, D. (1993). Nature 366, 701–704.

    Article  PubMed  CAS  Google Scholar 

  116. Serrano, M., Gomez-Lahoz, E., DePinho, R.A., Beach, D. and Bar-Sagi, D. (1995) Science 267, 249–252.

    Article  PubMed  CAS  Google Scholar 

  117. Morishita, R., Gibbons, G.H., Ellison, K.E., Nakajima, M., Zhang, L., Kaneda, Y., Ogihara, T. and Dzau, V.J. (1993) Proc. Natl. Acad. Sci. USA 90, 8474–8478.

    Article  PubMed  CAS  Google Scholar 

  118. Abe, J., Zhou, W., Taguchi, J., Takuwa, N., Miki, K., Okazaki, H., Kurokawa, K., Kumada, M. and Takuwa, Y. (1994) Biochem. Biophys. Res. Commun. 198, 16–24.

    Article  PubMed  CAS  Google Scholar 

  119. Riabowol, K., Draetta, G., Brizuela, L., Vandre, D. and Beach, D. (1989) Cell 57, 393–401.

    Article  PubMed  CAS  Google Scholar 

  120. O’Connor, P.M. and Kohn, K.W., 1992. Seminars in Cancer Biol. 3, 409–416.

    CAS  Google Scholar 

  121. Fisher, D.E. (1994) Cell 78, 539–542.

    Article  PubMed  CAS  Google Scholar 

  122. Smets, L.A. (1994) Anti-Cancer Drugs 5, 3–9.

    Article  PubMed  CAS  Google Scholar 

  123. Tobey, R.A. (1975) Nature 254, 245–247.

    Article  PubMed  CAS  Google Scholar 

  124. Rao, A.P. and Rao, P.N. (1976) J. Natl. Cancer Inst. 57, 1139–1143.

    PubMed  CAS  Google Scholar 

  125. Kimler, B.F., Schneiderman, M.H. and Leeper, D.B. (1978) Cancer Res. 38, 809–814.

    PubMed  CAS  Google Scholar 

  126. Kharbanda, S., Saleem, A., Datta, R., Yuan, Z.M., Weichselbaum, R. and Kufe, D. (1994) Cancer Res. 54, 1412–1414.

    PubMed  CAS  Google Scholar 

  127. Demarcq, C., Bunch, R.T., Creswell, D. and Eastman, A. (1994) Cell Growth and Different. 5, 983–993.

    CAS  Google Scholar 

  128. O’Connor, P.M., Ferris, D.K., White, G.A., Pines, J., Hunter, T., Longo, D.L. and Kohn, K.W. (1992) Cell Growth and Different. 3, 43–52.

    CAS  Google Scholar 

  129. Matsukawa, Y., Marui, N., Sakai, T., Satomi, Y., Yoshida, M., Matsumoto, K., Nishino, H. and Aoike, A. (1993) Cancer Res. 53, 1328–1331.

    PubMed  CAS  Google Scholar 

  130. Tsao, Y.P., D’Arpa, P. and Liu, L.F. (1992) Cancer Res. 52, 1817–1829.

    Google Scholar 

  131. Rowley, R. and Kort, L. (1989) Cancer Res. 49, 4752–4757.

    PubMed  CAS  Google Scholar 

  132. Lock, R.B. and Ross, W.E. (1990) Cancer Res. 50, 3761–3766.

    PubMed  CAS  Google Scholar 

  133. Lock, R.B. and Ross, W.E. (1990) Cancer Res. 50, 3767–3771.

    PubMed  CAS  Google Scholar 

  134. Lock, R.B. (1992) Cancer Res. 52, 1817–1822.

    PubMed  CAS  Google Scholar 

  135. Misra, N.C. and Roberts, D.W. (1975) Cancer Res. 35, 99–105.

    PubMed  CAS  Google Scholar 

  136. O’Connor, P.M., Ferris, D.K., Hoffmann, I., Jackman, J., Draetta, G. and Kohn, K.W. (1994) Proc. Natl. Acad. Sci. USA 91, 9480–9484.

    Article  CAS  Google Scholar 

  137. Meijer, L., Azzi, L. and Wang, J.Y.J. (1991) EMBO J. 10, 1545–1554.

    PubMed  CAS  Google Scholar 

  138. Dulic, V., Kaufmann, W.K., Wilson, S.J., Tlsty, T.D., Lees, E., Harper, J.W., Elledge, S.J. and Reed, S.I. (1994) Cell 76, 1013–1023.

    Article  PubMed  CAS  Google Scholar 

  139. Meikrantz, W., Gisselbrecht, S., Tarn, S.W. and Schlegel, R. (1994) Proc. Natl. Acad. Sci. USA 91, 3754–3758.

    Article  PubMed  CAS  Google Scholar 

  140. Shi, L., Nishioka, W.K., Th’ng, J., Bradbury, E.M., Litchfield, D.W. and Greenberg, A.H. (1994) Science 263, 1143–1145.

    Article  PubMed  CAS  Google Scholar 

  141. Fotedar, R. Flatt, J., Gupta, S., Margolis, R.L., Fittzgerald, P., Messier, H. and Fotedar, A. (1995) Molecul. Cellul. Biol. 15, 932–942.

    CAS  Google Scholar 

  142. Lazebnik, Y.A., Cole, S., Cooke, C.A., Nelson, W.G. and Earnshaw, W.C. (1993). J. Cell Biol. 123, 7–22.

    Article  PubMed  CAS  Google Scholar 

  143. Oberhammer, F.A., Hochegger, K., Fröschl, G., Tiefenbacher, R. and Pavelka, M. (1994) J. Cell Biol. 126, 827–837.

    Article  PubMed  CAS  Google Scholar 

  144. Norbury, C., MacFarlane, M., Fearnhead, H. and Cohen, G.M. (1994) Biochem. Biophys. Res. Commun. 202, 1400–1406.

    Article  PubMed  CAS  Google Scholar 

  145. Horiguchi-Yamada, J., Yamada, H., Nakada, S., Ochi, K. and Nemoto, T. (1994) Molecul. Cellul. Biochem. 132, 31–37.

    Article  CAS  Google Scholar 

  146. Kiyokawa, H., Richon, V.M., Rifkind, R.A. and Marks, P.A. (1994) Molecul. Cellul. Biol. 14, 7195–7203.

    CAS  Google Scholar 

  147. Ohkubo, Y., Kishimoto, T., Nakata, T., Yasuda, H. and Endo, T. (1994) Exp. Cell Res. 214, 270–278.

    Article  PubMed  CAS  Google Scholar 

  148. Kato, J.Y. and Sherr, C.J. (1993) Proc. Natl. Acad. Sci. USA 90, 11513–11517.

    Article  PubMed  CAS  Google Scholar 

  149. Parker, S., Eichele, G., Zhang, P., Rawls, A., Sands, A.T., Bradley, A., Olson, E.N., Harper, J.W. and Elledge, S.J. (1995) Science 267, 1024–1027.

    Article  PubMed  CAS  Google Scholar 

  150. Halevy, O., Novitch, B.G., Spicer, D.B., Skapek, S.X., Rhee, J., Harmon, G.J., Beach, D. and Lassar, A.B. (1995) Science 267, 1018–1021.

    Article  PubMed  CAS  Google Scholar 

  151. Shapek, S.X., Rhee, J., Spicer, D.B. and Lassar, A.B. (1995) Science 267, 1022–1024.

    Article  Google Scholar 

  152. Hrushesky, W.J.M. (1992) in The Chemotherapy Source Book (Perry, M.C., ed.), chapter 12, pp. 165–212, Williams & Wilkins, Baltimore, USA.

    Google Scholar 

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  1. CNRS, Station Biologique, B.P. 74, 29682, Roscoff cedex, France

    Laurent Meijer

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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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Meijer, L. (1995). Chemical inhibitors of cyclin-dependent kinases. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_29

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  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_29

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