Onset of chromosome segregation at the metaphase to anaphase transition of the cell cycle

  • Marcel Dorée
  • Christian Le Peuch
  • Nathalie Morin
Part of the Progress in Cell Cycle Research book series (PCCR)

Abstract

Chromosome segregation is one of the most important acts in the life of the cell. Unequal inheritance of chromosomes (aneuploidy) is a cause of a number of disorders, particularly in humans, even though eukaryotic cells can arrest or delay the transition from metaphase to anaphase if an event critical to the completion of metaphase is impaired. In this report, we review recent advances in our knowledge of how the complex process of chromosome segregation is coupled with cell cycle progression, and starts at onset of anaphase with sister chromatids separation of the replicated chromosomes.

Keywords

Germinal Polypeptide Hunt Aspergillus Rosen 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Marcel Dorée
    • 1
  • Christian Le Peuch
    • 1
  • Nathalie Morin
    • 1
  1. 1.Centre de Recherches de Biochimie MacromoléculaireCNRS UPR 9008 and INSERM U 249Montpellier cedexFrance

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