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The regulation and functions of cdk7

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

cdk7 started its life rather anonymously as a kinase called MO15, identified during a search for cDNA’s which encode protein kinases related to cdc2. For several years its function remained obscure, but during the last 18 months MO15 has revealed itself as the catalytic subunit of cdk activating kinase, associating with at least two other subunits including a new cyclin, cyclin H. MO15(cdk7) has therefore been established paradoxically as both a new member and a regulator of the cyclin dependent kinase family. New evidence now suggests that cdk7 is also involved in the processes of transcription initiation and DNA repair, associating with the general transcription factor TFIIH. The enigma of cdk7 is likely to remain for a while yet, and perhaps even more surprises are in store.

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Author information

Authors and Affiliations

  1. Department of Anatomy, University of Birmingham, Birmingham, B15 2TT, United Kingdom

    John Shuttleworth

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  1. John Shuttleworth
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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© 1995 Springer Science+Business Media New York

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Shuttleworth, J. (1995). The regulation and functions of cdk7. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_18

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  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5731-5

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