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The fission yeast Nim1/Cdr1 kinase: A link between nutritional state and cell cycle control

  • Pascale Belenguer
  • Laetitia Pelloquin
  • Véronique Baldin
  • Marie-Louise Oustrin
  • Bernard Ducommun
Part of the Progress in Cell Cycle Research book series (PCCR)

Abstract

Close connections appear to exist between extra-cellular signals that regulate cell proliferation and the protein kinases that control the cell cycle machinery. The fission yeast nim1 kinase is an inducer of cdc2 kinase activity acting through the inhibition of wee1 kinase. Nim1 function is required for a correct cellular response to nutritional starvation. In the absence of nim1, starved cells are unable to decrease their size at mitosis, to arrest their cycle in G1 and to enter G0. Here, we review our current knowledge on the role and the regulation of nim1 in connecting cell cycle and nutritional pathways.

Keywords

Fission Yeast Nitrogen Starvation Schizosaccharomyces Pombe Nitrogen Free Medium Cdc2 Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Pascale Belenguer
    • 1
  • Laetitia Pelloquin
    • 1
  • Véronique Baldin
    • 1
  • Marie-Louise Oustrin
    • 1
  • Bernard Ducommun
    • 1
  1. 1.Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRSUniversité Paul SabatierToulouse cedexFrance

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