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The Multiple Roles of Macrophages in Wound Healing

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Book cover The Molecular and Cellular Biology of Wound Repair

Abstract

The process of wound healing is associated with dynamic changes in the type and density of various infiltrating cell populations (Ross and Benditt, 1961). Tissue injury, in response to a variety of agents (e.g., surgical trauma or burns), rapidly induces a nonspecific inflammation probably as a result of blood coagulation, with accompanying platelet aggregation and activation of the complement and kinin systems (see Chapters 2 and 3). The first blood leukocytes to be attracted and demobilized at the site of tissue injury are neutrophils, the number of which increases steadily before peaking at 24–48 hr (see Chapter 6). The main function of neutrophils is apparently to destroy bacteria introduced into the tissue during injury. However, in the absence of gross infection, depletion of circulating neutrophils in guinea pigs by treatment with antineutrophil serum has no effect on the subsequent healing of experimentally induced wounds (Simpson and Ross, 1972).

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Authors and Affiliations

  1. Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, 80206, USA

    David W. H. Riches

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  1. David W. H. Riches
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  1. National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    R. A. F. Clark  & P. M. Henson  & 

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© 1988 Springer Science+Business Media New York

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Riches, D.W.H. (1988). The Multiple Roles of Macrophages in Wound Healing. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1795-5_8

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