Neutrophil Emigration, Activation, and Tissue Damage

  • Marcia G. Tonnesen
  • G. Scott Worthen
  • Richard B. JohnstonJr.


The early inflammatory phase of wound healing is characterized by a rapid accumulation of neutrophils. Despite this observation, the neutrophil does not appear to play a central or essential role in the wound healing process per se. The classic study by Simpson and Ross (1972), in which wound repair was monitored in guinea pigs depleted of neutrophils by the administration of antineutrophil serum, failed to demonstrate that either wound debridement or formation of granulation tissue is dependent on the presence of neutrophils.


Human Neutrophil Chronic Granulomatous Disease Neutrophil Elastase Cationic Protein Neutrophil Migration 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Marcia G. Tonnesen
    • 1
    • 4
  • G. Scott Worthen
    • 2
  • Richard B. JohnstonJr.
    • 3
  1. 1.Department of PediatricsNational Jewish Center for Immunology and Respiratory MedicineDenverUSA
  2. 2.Department of MedicineNational Jewish Center for Immunology and Respiratory MedicineDenverUSA
  3. 3.Department of PediatricsThe University of Pennsylvania School of Medicine and The Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  4. 4.Dermatology ServiceVeterans’ Administration Medical CenterDenverUSA

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