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Platelets and Response to Injury

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The Molecular and Cellular Biology of Wound Repair

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Abstract

Our understanding of the participatory role of platelets in biologic processes other than hemostasis and coagulation is rapidly evolving. Platelets are implicated in the maintenance of capillary integrity and wound healing. Platelets may also contribute to the acceleration of atherogenesis, as the activation of these cells promotes vascular injury and platelets promote cholesterol accumulation within smooth muscle cells and macrophages. This chapter addresses the structure, function, and modes of activation of platelets as they relate to the potential role of these cells in certain immunologically mediated and inflammatory diseases in which alterations of blood vessel function and integrity occur.

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  1. Veterans Administration Medical Center, University of California San Diego, San Diego, California, 92161, USA

    Robert A. Terkeltaub

  2. Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Mark H. Ginsberg

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  1. National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    R. A. F. Clark  & P. M. Henson  & 

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Terkeltaub, R.A., Ginsberg, M.H. (1998). Platelets and Response to Injury. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_2

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