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Angiogenesis

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

The response of vascularized tissue to injury depends in part upon complex and diverse micro vascular endothelial cell activities. Although various aspects of the inflammatory response have been known and written about for approximately 4000 years, the central importance of the vascular endothelial cell in this phenomenon has only recently been appreciated (Folkman and Hauden-schild, 1980; Folkman, 1984; Macleod, 1971; Ryan and Majino, 1977). Since Cohnheim’s landmark paper (1889) describing the changes in microvasculature during the acute phases of inflammation, a large research effort has been directed at elucidating the roles of plasma, serum, and cellular and tissue factors involved in the inflammatory response (Macleod, 1971; Ryan and Majino, 1977). However, specific endothelial cell responses to acute and chronic inflammation have only recently been appreciated and are thus less well studied and documented. The great disparity in information is largely due to the absence, until relatively recently, of appropriate methodologies (e.g., electron microscopy, cell culture systems, and modern cell physiology and biochemistry) with which to study the microvascular endothelial cell and its complex metabolism (Madri and Williams, 1983; Folkman and Haudenschild, 1980; Kramer et al., 1984).

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  1. Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Joseph A. Madri & Bruce M. Pratt

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  1. Joseph A. Madri
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  1. National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    R. A. F. Clark  & P. M. Henson  & 

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Madri, J.A., Pratt, B.M. (1988). Angiogenesis. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_15

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