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The Molecular and Cellular Biology of Wound Repair pp 273–280Cite as

The Role of Growth Factors in Tissue Repair IV

Type β-Transforming Growth Factor and Stimulation of Fibrosis

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Abstract

Type β-transforming growth factor (TGF-β) is a low-molecular-weight protein with a broad array of biologic effects, including the ability both to stimulate and inhibit the proliferation of cells in culture (Tucker et al., 1984; Roberts et al., 1985; Sporn et al., 1986). This chapter focuses on a single aspect of TGF-β action: its ability to induce a striking wound-healing response in several whole-animal and cell-culture model systems. These results, considered with experiments showing storage of TGF-β in platelets and release of TGF-β during platelet degranulation, strongly suggest that this growth factor has an important physiologic role as an endogenous mediator of wound repair and fibrosis.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics, Center for Reproductive Sciences, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, USA

    Rchard K. Assoian

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  1. Rchard K. Assoian
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Editors and Affiliations

  1. National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    R. A. F. Clark  & P. M. Henson  & 

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© 1988 Springer Science+Business Media New York

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Assoian, R.K. (1988). The Role of Growth Factors in Tissue Repair IV. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-1795-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5725-4

  • Online ISBN: 978-1-4615-1795-5

  • eBook Packages: Springer Book Archive

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