The Role of Growth Factors in Tissue Repair III
Fibroblast growth factor (FGF) was first described by Gospodarowicz and co-workers as an activity derived from bovine brain or pituitary tissue (Gospodarowicz, 1974). As the name suggests, FGF was found to be mitogenic for fibroblasts in culture as well as endothelial cells and several other types of mesoderm-derived cells. It was first believed that FGF resulted from the degradation of myelin basic protein (Westall et al., 1978), but this was later found not to be the case (Thomas et al., 1980). Further characterization of the activity revealed that the primary mitogen from brain was different than that isolated from pituitary. These two factors were named acidic and basic FGF because they had similar if not identical biologic activities but differed in their iso-electric points.
KeywordsMigration Hydrocortisone Cysteine Heparin Retina
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