Freezing and Vitrification of Red Cells, Recollections and Predictions

  • H. T. Meryman
Part of the Developments in Hematology and Immunology book series (DIHI, volume 36)


The subject of red cell freezing has been reviewed repeatedly since the first report of glycerol cryoprotection by Audrey Smith in 1950 [1]. At least four books on the subject have been published [2-5] and the science, the technology and the applications have been so exhaustively documented that yet another review of red cell freezing seems largely redundant. What is still missing, however, are those obscure and statistically insignificant events that never found their way into print, often for good reason, and known only to a few of the rapidly diminishing ranks of octogenarians who were there at the creation. The goal of this review, therefore, is not only to summarize the topic as it is understood today but also to recall the human side of some of the milestones in the development of red cell freezing, many of them autobiographical.


Glycerol Concentration Hydroxyethyl Starch Freezing Injury High Glycerol Freeze Blood 
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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • H. T. Meryman
    • 1
  1. 1.Cryopreservation and Transfusion ProgramNaval Medical Research CenterSilver SpringUSA

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