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Cell Signaling: Serine/Threonine Protein Kinases and Traumatic Brain Injury

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Brain Injury

Part of the book series: Molecular and Cellular Biology of Critical Care Medicine ((MCCM,volume 2))

Abstract

Traumatic brain injury (TBI) is a complex interaction of primary and secondary processes that may require days to evolve. Injury processes are related to the magnitude and type of TBI and the resulting systemic as well as neural complications. In this brief review we will focus on several features of neurotransmitter and trophic factor proximal signal transduction that normally function in the transfer of neuronal information within and between neurons that can become pathological mediators and modulators. Over the last several years advances have been made in identifying the intracellular pathways for trophic factor signaling in the brain and a greater understanding of interactions between neurotransmitter and trophic signals has resulted; however, the complexity of these interactions suggests we still have much to learn. This review will focus on recent insights into how interactions between trophic and neurotransmitter signals may participate in neuronal survival after TBI.

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Authors and Affiliations

  1. University of Pittsburgh, Pittsburgh, PA, USA

    Larry Jenkins, C. Edward Dixon, Grant Peters, Wei-Min Gao, Xiaopeng Zhang, P. David Adelson & Patrick M. Kochanek

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  1. Larry Jenkins
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  2. C. Edward Dixon
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  3. Grant Peters
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  4. Wei-Min Gao
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  5. Xiaopeng Zhang
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  6. P. David Adelson
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  7. Patrick M. Kochanek
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Editor information

Editors and Affiliations

  1. Pediatric Critical Care Medicine, Children’s Hospital of Pittsburgh, Pittsburgh, PA, 15213, USA

    Robert S. B. Clark M.D.

  2. Safar Center for Resuscitation Research, Pittsburgh, PA, USA

    Patrick Kochanek M.D.

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© 2001 Springer Science+Business Media New York

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Jenkins, L. et al. (2001). Cell Signaling: Serine/Threonine Protein Kinases and Traumatic Brain Injury. In: Clark, R.S.B., Kochanek, P. (eds) Brain Injury. Molecular and Cellular Biology of Critical Care Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1721-4_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1721-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5695-0

  • Online ISBN: 978-1-4615-1721-4

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