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Herpesvirus Homologues of Cellular Genes

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Molecular Evolution of Viruses — Past and Present

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Abstract

For millions of years viruses have adapted strategies to interfere with the immune defense of the host, which in turn has to deal with this challenge. In general the antiviral defense remains one step behind the pathogen. To achieve this strategic advantage large DNA-containing Viruses encode cellular homologues that mimic or counteract key molecules of the host immune system. Understanding how these cellular homologues enable the viruses to evade the antiviral defense and persist in the host for the lifetime will ultimatively lead also to a better understanding of the principle functions of the immune system. In this review we focused on cellular homologues encoded by human herpesviruses and discuss the functional consequences of their expression.

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Authors and Affiliations

  1. Department of Medical Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany

    Martin Raftery, Anke Müller & Günther Schönrich

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  1. Martin Raftery
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  2. Anke Müller
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  3. Günther Schönrich
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Editors and Affiliations

  1. Department of Molecular Virology, The Hebrew University of Jerusalem, Jerusalem, Israel

    Yechiel Becker

  2. Institute of Medical Virology, Ruprecht-Karls University, Heidelberg, Germany

    Gholamreza Darai

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Raftery, M., Müller, A., Schönrich, G. (2000). Herpesvirus Homologues of Cellular Genes. In: Becker, Y., Darai, G. (eds) Molecular Evolution of Viruses — Past and Present. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1707-8_6

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  • DOI: https://doi.org/10.1007/978-1-4615-1707-8_6

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