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Prolactin pp 247–264Cite as

Prolactin Regulation of Cell Proliferation and Apoptosis

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Part of the book series: Endocrine Updates ((ENDO,volume 12))

Abstract

The idea that PRL may function as a stimulator of a trophic response in a broad spectrum of tissues is one that has evolved slowly since its initial discovery nearly 70 years ago. In large part, the comparative reluctance to embrace a role for PRL as a regulator of growth in tissues beyond those involved in reproduction and nurturing of the young, is due to its well characterized and extensively studied effects in the mammary gland in which it is essential for lactation and for which it was originally named (1). Indeed, itsF effect to stimulate proliferation in the crop-sac, together with the formation of crop-milk in pigeons and doves as well as to induce lactation in mammals led to identification of PRL as a new anterior pituitary hormone (2, 3).

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  1. University of Cincinnati Medical Center, Cincinnati, OH, USA

    Arthur R. Buckley

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  1. University of Cincinnati, USA

    Nelson D. Horseman

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Buckley, A.R. (2001). Prolactin Regulation of Cell Proliferation and Apoptosis. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1683-5_13

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