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Actions of Prolactin in the Prostate Gland

  • Chapter
Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

Abstract

The study of normal prostate development and prostate pathobiology has historically been mainly focused on actions of androgens. Androgens regulate proliferation and differentiation of prostatic cells. Although indispensable, androgens alone are not sufficient for the normal development and function of the prostate gland (1). The physiological importance of non-androgenic hormones and growth factors is well established. Prolactin (PRL) is one factor with the potential to act on normal prostate, alone or synergistically, with androgens (2). The possibility of PRL involvement in the progression of prostate cancer was first indicated in clinical studies more than 25 years ago. Additional clinical observations are presented along with findings in experimental work, providing possible explanations for PRL action in normal and pathophysiological conditions of the prostate gland.

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Authors and Affiliations

  1. Research Center for Endocrinology and Metabolism, Department of Physiology, Göteborg University, Sweden

    J. Kindblom, K. Dillner, J. Törnell & H. Wennbo

  2. AstraZeneca Transgenic Center, Mölndal, Sweden

    J. Kindblom, K. Dillner, J. Törnell & H. Wennbo

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  1. J. Kindblom
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  2. K. Dillner
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  3. J. Törnell
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  4. H. Wennbo
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  1. University of Cincinnati, USA

    Nelson D. Horseman

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Kindblom, J., Dillner, K., Törnell, J., Wennbo, H. (2001). Actions of Prolactin in the Prostate Gland. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-1683-5_12

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