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Hypothalamic Control of Prolactin Synthesis and Secretion

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Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

Abstract

The synthesis and release of prolactin (PRL) by the lactotrophs is subjected to multiple regulators. These can be classified into four broad categories: endocrine, paracrine, juxtacrine and autocrine. Endocrine agents originate from the hypothalamus, gonads and the neural lobe of the pituitary and reach the lactotrophs via a humoral route. Paracrine factors are produced by cells of the intermediate and anterior lobes and reach their target cells by diffusion. Juxtacrine interactions emanate from extracellular matrix of cells adjacent to the lactotrophs. Autocrine agents are synthesized by the lactotrophs themselves. Consequently, the overall secretory activity of the lactotrophs reflects a balance between local and distant releasing and inhibiting factors Figure 1-1.

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  1. University of Cincinnati, Cincinnati, OH, USA

    Nira Ben-Jonathan

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  1. University of Cincinnati, USA

    Nelson D. Horseman

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Ben-Jonathan, N. (2001). Hypothalamic Control of Prolactin Synthesis and Secretion. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_1

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