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Role of Invasive Devices in the Pathogenesis of Nosocomial Pneumonia

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Critical Care Infectious Diseases Textbook

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Abstract

Nosocomial pneumonia is still a common problem, especially in intubated and mechanically ventilated patients. The endotracheal tube contributes substantially to the pathogenesis of pneumonia in these patients, because it facilitates microaspiration and impairs host defenses. Common nosocomial pathogens like Pseudomonas aeruginosa are known to produce exopolysaccha-ride and generate the complex biofilm structure, which allows adhesion to abiotic surfaces and protection from antibiotic action. Multiple studies have identified bacterial biofilm on the inner lumen of endotracheal tubes, which represent a permanent source of infectious material. Endotracheal tubes, removed from patients with ventilator-associated pneumonia are covered more frequently with biofilm than those of uninfected controls but it remains unclear whether this represents a source of infection or secondary contamination.

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Authors
  1. Torsten T. Bauer
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  2. Ricard Ferrer
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  3. Antonio Torres
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Editor information

Editors and Affiliations

  1. Hospital Universitari Joan XXIII, Tarragona, Spain

    Jordi Rello M.D., Ph.D.

  2. University Rovira & Virgili, Tarragona, Spain

    Jordi Rello M.D., Ph.D.

  3. Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona, Spain

    Jordi Valles M.D., Ph.D.

  4. Washington University School of Medicine, St. Louis, Missouri, USA

    Marin H. Kollef M.D.

  5. Barnes-Jewish Hospital, St. Louis, Missouri, USA

    Marin H. Kollef M.D.

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Bauer, T.T., Ferrer, R., Torres, A. (2001). Role of Invasive Devices in the Pathogenesis of Nosocomial Pneumonia. In: Rello, J., Valles, J., Kollef, M.H. (eds) Critical Care Infectious Diseases Textbook. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1679-8_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1679-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5674-5

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