Abstract
Nosocomial problems with antibiotic resistant microorganisms have occurred in several stages over the last 40 years. After the first recognition of antibiotic resistance of S. aureus to penicillin in the 1950s, emergence of Gram-negative bacteria resistant to multiple antibiotics became prominent in the 1970s and 1980s. Concerns about (multi-)resistance among nosocomial Gram-positive bacteria re-emerged in the late 1980s. Currently, the most important nosocomial resistance problems on a global scale are caused by methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), Enterobacteriaceae with plasmid-encoded extended-spectrum beta-lactamases (ESBL), and Pseudomonas aeruginosa.
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Bonten, M.J.M. (2001). Epidemic Infections in the ICU: Multiresistant Microorganisms. In: Rello, J., Valles, J., Kollef, M.H. (eds) Critical Care Infectious Diseases Textbook. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1679-8_21
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