An Historical and Phylogenetic Perspective of Islet-Cell Development

  • Ole D. Madsen
  • Palle Serup
  • Jan Jensen
  • Helle V. Petersen
  • R. Scott Heller
Part of the Endocrine Updates book series (ENDO, volume 11)


Before the discovery of insulin the diagnosis of diabetes mellitus was equivalent to being sentenced to death. It was thus a miracle that insulin treatment would rescue the lives of diabetics, and Banting and MacLeod were awarded the Nobel Prize in 1923 for their pioneering work in Toronto (1). As time went by, it became apparent that diabetic patients suffer from late complications such as neuropathy, retinopathy, vascular diseases and kidney failure. Such complications are now ascribed to inappropriate fluctuations in blood glucose levels as revealed in recent clinical trials (DCCT &UKPDS) (2-4). Insulin thus provides a treatment of diabetes - not a cure.


Islet Cell Insulin Gene Pancreatic Development Pancreas Development Insulin Promoter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Ole D. Madsen
    • 1
  • Palle Serup
    • 1
  • Jan Jensen
    • 1
  • Helle V. Petersen
    • 1
  • R. Scott Heller
    • 1
  1. 1.Hagedorn Research InstituteGentofteDenmark

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