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Gene Therapy for Asthma

  • Chapter
Gene Therapy for Acute and Acquired Diseases

Abstract

Asthma is a disease which is increasing in frequency and severity despite advances in the understanding of its physiology and treatment. Gene therapy raises the hope for treatment of otherwise incurable illnesses, such as asthma. Especially in need of new therapies are patients who require continuous oral glucocorticoids (GC), the so called GC-dependent patients. These patients are those who require particular medical attention, they are frequently admitted to hospital and they represent over 50% of the total costs associated with asthma. No satisfactory alternative therapy is currently available for these individuals. A variety of gene-based strategies have been proposed for inflammatory and immunological disorders. Although there are very few published works that directly bear on gene therapy for asthma, it is the purpose of this review to consider its application to asthma therapy.

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Literature Cited

  1. Burr ML, Butland BK, King S, Vaughan WE. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child. 1989; 64:1452–1456.

    Article  PubMed  CAS  Google Scholar 

  2. Woolcock AJ. Worldwide differences in asthma prevalence and mortality. Chest 1986;90:S40–S45.

    Article  Google Scholar 

  3. Bousquet J, Hatton F, Godard Ph, Michel FB. Asthma mortality in France. J Allergy Clin Immunol. 1987;80:389–394.

    Article  PubMed  CAS  Google Scholar 

  4. Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med. 1992; 326:862–866.

    Article  PubMed  CAS  Google Scholar 

  5. Gough J. Post-mortem differences in “asthma” and chronic bronchitis. ActaAllergol. 1961; 16:391–399.

    CAS  Google Scholar 

  6. Djukanovic R, Roche WR, Wilson JW, Beasley CRW. Twentyman OP, Howarth PH, Holgate ST. State of the Art: Mucosal inflammation in asthma. Am Rev Respir Dis. 1990; 142:434–457.

    PubMed  CAS  Google Scholar 

  7. Kay AB. Asthma and inflammation. J Allergy Clin Immunol. 1991;87:893-910.

    Article  PubMed  CAS  Google Scholar 

  8. Barnes PJ, Greening AP, Crompton GK. GC resistance in asthma. Am J Respir Crit Care Med. 1995; 152:S125–S142.

    PubMed  CAS  Google Scholar 

  9. Moss RB. Alternative pharmacotherapies for GC-dependent asthma. Chest 1995; 107:817–825.

    Article  PubMed  CAS  Google Scholar 

  10. Wilkinson JR, Lane SJ, Lee TH. Effects of GC on cytokine generation and expression of activation antigens by monocytes in bronchial asthma. Int Arch Allergy Appl Immunol. 1991; 94:220–221.

    Article  PubMed  CAS  Google Scholar 

  11. Carmichael J, Paterson IC, Diaz P, Crompton GK, Kay AB, Grant IWB. GC resistance in chronic asthma. Br Med J. 1982;282:1419–1422.

    Article  Google Scholar 

  12. Corrigan CJ, Brown PH, Barnes NC, Tsai JJ, Frew AJ, Kay AB. GC resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of GC and cyclosporin A. Am Rev Respir Dis. 1991; 144:1026–1032.

    Article  PubMed  Google Scholar 

  13. Alvarez J, Surs W, Leung DY, Ikle D, Gelfand EW, Szefler SJ. GC-resistant asthma: immunologic and pharmacologic features. J Allergy Clin Immunol. 1992;89:714–721.

    Article  PubMed  CAS  Google Scholar 

  14. Kam JC, Szefler SJ, Surs W, Sher ER, Leung DYM. Combination IL-2 and IL-4 reduces GC receptor-binding affinity and T cell response to GC. J Immunol. 1993; 151:3460–3466.

    PubMed  CAS  Google Scholar 

  15. Sher E, Leung DYM, Surs W, Kam JC, Zieg G, Kamada AK, Szefler SJ. GC resistant asthma. Cellular mechanisms contributing to inadequate response to GC therapy. J Clin Invest. 1994; 93:33–39.

    Article  PubMed  Google Scholar 

  16. Adcock I A, Lane SJ, Brown CR, Peters MJ, Lee TH, Barnes PJ. Differences in binding of GC receptor to DNA in GC-resistant asthma. J Immunol. 1995; 154:3500–3505.

    PubMed  CAS  Google Scholar 

  17. Adcock IA, Lane SJ, Brown CR, Lee TH, Barnes PJ. Abnormal GC receptor/API interaction in GC-resistant asthma. J Exp Med. 1995; 182:1951–1958.

    Article  PubMed  CAS  Google Scholar 

  18. Leung D, Hamid Q, Vottero A, Szefler S, Surs W, Minshall E, Chrousos G, Klemm D. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med. 1997; 186:1567–1574.

    Article  PubMed  CAS  Google Scholar 

  19. Leung DYM, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, Hamid Q. Dysregulation of interleukin 4, interleukin 5, and interferon y gene expression in GC-resistant asthma. J Exp Med. 1995; 181:33–40.

    Article  PubMed  CAS  Google Scholar 

  20. Lane SJ, Arm JP, Staynov DZ, Lee TH. Chemical mutational analysis of the human GC receptor cDNA in GC-resistant bronchial asthma. Am J Respir Cell Mol Biol. 1994; 11:42–48.

    PubMed  CAS  Google Scholar 

  21. Rosenfeld MA, Collins FS. Gene therapy for cystic fibrosis. Chest. 1996;109:241–252.

    Article  PubMed  CAS  Google Scholar 

  22. Karol MH. Animal models of occupational asthma. Eur Respir J. 1994; 7:555–568.

    Article  PubMed  CAS  Google Scholar 

  23. Lack G, Renz H, Saloza J, Bradley KL, Loader J, Leung DYM, Larsen G, Gelfand EW. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airway function in a murine model of allergen sensitization. J Immunol. 1994; 152:2546–2554.

    PubMed  CAS  Google Scholar 

  24. Kung TT, Stelts DM, Zurcher JA, Adams III GK, Egan RW, Kreutner W, Watnick AS, Jones H, Chapman RW. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL5 antibody. Am J Respir Cell Mol Biol. 1995; 13:360–365.

    PubMed  CAS  Google Scholar 

  25. Blyth DI, Pedrick MS, Savage TJ, Hessel EM, Fattah D. Lung inflammation and epithelial changes in a murine model of atopic asthma. Am J Respir Cell Mol Biol. 1996; 14:425–438.

    PubMed  CAS  Google Scholar 

  26. Nakajima H, Iwamoto I, Tomoe S, Matsumura R, Tomioka H, Takatsu K, Yoshida S. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis. 1992; 146:374–377.

    PubMed  CAS  Google Scholar 

  27. Garlisi CG, Falcone A, Kung TT, Stelts D, Pennline KJ, Beavis AJ, Smith SR, Egan RW, Umland SP. T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice. Clin Immunol Immunopathol. 1995; 75:75–83.

    Article  PubMed  CAS  Google Scholar 

  28. Kung TT, Stelts D, Zurcher J, Jones H, Umland SP, Kreutner W, Egan, RW, Chapman RW. Mast cells modulate allergic pulmonary eosinophilia in mice. Am J Respir Cell Mol Biol. 1995; 12:404–409.

    PubMed  CAS  Google Scholar 

  29. Wegner CD, Gundel RH, Reilly P, Haynes N, Letts G, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science. 1990;24:456–459.

    Article  Google Scholar 

  30. Gundel RH, Wegner CD, Torcellini CA, Letts LG. The role of intercellular adhesion molecule-1 in chronic airway inflammation. Clin Exp Allergy. 1992; 22:569–575.

    Article  PubMed  CAS  Google Scholar 

  31. Miller N, Vile R. Targeted vectors for gene therapy. FASEB J. 1995; 9:190–1995.

    PubMed  CAS  Google Scholar 

  32. Curiel DT, Pilewski JM, Albelda SM. Gene therapy approaches for inherited and acquired lung diseases. Am J Respir Cell Mol Biol. 1996; 14:1–18.

    Article  PubMed  CAS  Google Scholar 

  33. Abelda SM, Wiewrodt R, Zuckerman JB. Gene therapy for lung disease: hype or hope? Ann Intern Med 2000; 132:649–660.

    Google Scholar 

  34. Bousquet J, Chanez P, Lacoste JY, Barn on G, Ghavanian N, Enander I, Venge P, Ahlstedt A, Simony-Lafontaine J, Godard P, Michel FB. Eosinophilic inflammation in asthma. N Engl J Med. 1990; 323:1033–1039.

    Article  PubMed  CAS  Google Scholar 

  35. Metzger WJ, Richerson HB, Worden K, Monick M, Hunninghake GW, Bronchoalveolar lavage of allergic asthmatic patients following allergen bronchoprovocation. Chest. 1986; 89:477–483.

    Article  PubMed  CAS  Google Scholar 

  36. Lukacs NW, Strieter RM, Kunkel SL. Leukocyte infiltration in allergic airway inflammation. Am J Respir Cell Mol Biol. 1995; 13:1–6.

    Article  PubMed  CAS  Google Scholar 

  37. Woolley KL, Adelroth E, Woolley MJ, Jordana M, O’Byrne PM. Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma. Eur Respir J. 1994; 7:1576–1584.

    Article  PubMed  CAS  Google Scholar 

  38. Hamid Q, Azzawi M, Yin S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JW, Jeffery PK, Quint DJ, Kay AB. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest. 1991; 87:1541–1546.

    Article  PubMed  CAS  Google Scholar 

  39. Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR. Activation of CD4+ T cells, increased Th2-type cytokine mRNA expression and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol. 1993;92:313–324.

    Article  PubMed  CAS  Google Scholar 

  40. Das AM, Williams TJ, Lobb R, Nourshargh S. Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD 18 and VLA-4, in a guinea-pig model. Immunology. 1995; 84:41–46.

    PubMed  CAS  Google Scholar 

  41. Laberge S, Rabb H, Issekutz TB, Martin JG. Role of VLA-4 and LFA-1 in allergen-induced airway hyperresponsiveness and lung inflammation in the rat. Am J Respir Crit Care Med. 1995; 151:822–829.

    PubMed  CAS  Google Scholar 

  42. Abraham WM, Sielczak MW, Ahmed A, Cortes A, Lauredo IT, Kim J, Pepinsky P, Benjamin CD, Leone DR, Lobb RR, Weller PF. α4-Integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest. 1994; 93:776–787.

    Article  PubMed  CAS  Google Scholar 

  43. Mauser PJ, Pitman AM, Fernandez X, Foran SK, Adams HI GK, Kreutner W, Egan RW, Chapman RW. Effects of an antibody to IL-5 in a monkey model of asthma. Am J Respir Crit Care Med. 1995; 152:467–472.

    PubMed  CAS  Google Scholar 

  44. Brusselle G, Kips J, Bluethmann H, Pauwels R. Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am J Respir Cell Mol Biol. 1995; 12:254–259.

    PubMed  CAS  Google Scholar 

  45. Ohkawara Y, Yamauchi K, Maruyama N, Hoshi H, Iohno I, Honna M, Tanno Y, Tamura G, Shirato K, Ohtani H. In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with airflow limitation: in vivo evidence of VCAM-l/VLA-4 interaction in selective eosinophil infiltration. Am J Respir Cell Mol Biol. 1995; 12:4–12.

    PubMed  CAS  Google Scholar 

  46. Montefort S, Gratziou C, Goulding D, Polosa R, Haskard DO, Howarth PH, Holgate ST, Caroll MP. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local antigen challenge of sensitized asthmatic airways. J Clinlnvest. 1994; 93:1411–1421.

    Article  CAS  Google Scholar 

  47. Sun J, Elwood W, Haczku A, Barnes PJ, Hellewell P G, Chung KF. Contribution of intercellular adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitized brown-norway rats. Int Arch Allergy Immunol. 1994; 104:291–295.

    Article  PubMed  CAS  Google Scholar 

  48. Rabb H, Olivenstein AR, Issekutz TB, Renzi PM, Martin JG, Pantano R, Seguin S. The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat. Am J Respir Crit Care Med. 1994; 149:1186–1191.

    PubMed  CAS  Google Scholar 

  49. Watson ML, Smith D, Bourne AD, Thompson RC, Westwick J. Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway reactivity, pulmonary eosinophil accumulation, and tumor necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist. Am J Respir Cell Mol Biol. 1994; 8:365–369.

    Google Scholar 

  50. Lefort J, Nahori MA, Ruffi C, Vargaftig B, Pretolani M. In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs. J Clin Invest. 1996; 97:1117–1121.

    Article  PubMed  CAS  Google Scholar 

  51. White SR, Strek ME, Kulp GV, Burch RA, Leff AR. Down-regulation of human eosinophil activation and degranulation by inhibition of phospholipase A2. J Clin Invest 1993; 91:2118–2125.

    Article  PubMed  CAS  Google Scholar 

  52. Smith WL. Prostanoid biosynthesis and mechanisms of action. Am J Physiol. 1992; 263:F181–F191.

    PubMed  CAS  Google Scholar 

  53. Geha RS. Regulation of IgE synthesis in humans. J Allergy Clin Immunol. 1992; 90:143–150.

    Article  PubMed  CAS  Google Scholar 

  54. Maliszewski CR, Fanslow WC. Soluble receptors for IL-1 and IL-4: biological activity and therapeutic potential. Trends Biotech. 1990; 8:324–329.

    Article  CAS  Google Scholar 

  55. Aversa G, Punnonen J, Cocks BG, de Waal Malefyt R, Vega F, Zurawski SM, Zurawsky G, de Vries J. An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J Exp Med. 1993; 178:2213–2218.

    Article  PubMed  CAS  Google Scholar 

  56. Boguniewicz M, Jaffe HS, Izu A, Sullinvan MJ, York D, Geha RS, Leung DYM. Recombinant IFN-y in treatment of patients with atopic dermatitis and elevated IgE levels. Am J Med. 1990; 88:365–370.

    Article  PubMed  CAS  Google Scholar 

  57. Li JTC, Yunginger JW, Reed CE, Jaffe HS, Nelson DR, Gleich GJ. Lack of suppression of IgE production by recombinant IFN-γ. A controlled trial in patients with allergic rhinitis. J Allergy Clin Immunol. 1990; 85:934–940.

    Article  PubMed  CAS  Google Scholar 

  58. Boguniewicz M, Schneider IC, Milgrom H, Newell D, Jaffe HS, Izu AE, Bucalo LR, Leung DYM. Treatment of GC-dependent asthma with recombinant interferon-gamma (rlFN-γ). J Allergy Clin Immunol. 1992; 89:A288.

    Google Scholar 

  59. Jaffe HA, Buhl R, Mastrangelli A, Holroyd KJ, Saltini C, Czerski D, Jaffe HS, Kramer S, Sherwin S, Crystal RG. Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant IFN-_ to the human lung. J Clin Invest. 1991; 88:297–302.

    Article  PubMed  CAS  Google Scholar 

  60. Boguniewicz M, Martin RJ, Martin BA, Torvik J, Celniker A, Williams M, Leung, DYM. Aerosolized recombinant interferon-gamma (rlFN-γ) in normal subjects and asthmatics. J Allergy Clin Immunol. 1993;91:A226.

    Google Scholar 

  61. Dow S., Schwarze J, Heath TD, Potter TA, Gelfand EW. 1999. Systemic and local interferon gamma gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice. Hum Gene Ther. 1999; 10:1905–14.

    Article  PubMed  CAS  Google Scholar 

  62. Li XM, Chopra RK, Chou TY, Schofield BH, Wills-Karp M, Huang SK. Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. J Immunol. 1996; 157:3216–9.

    PubMed  CAS  Google Scholar 

  63. Fanslow WCDM, Anderson DM, Grabstein KH, Clark EA, Cosman D, Armitage RJ. Soluble forms of CD40 inhibit biologic responses of human B cells. J Immunol. 1992; 149:655–660.

    PubMed  CAS  Google Scholar 

  64. Lustgarten J, Esshar Z. Specific elimination of IgE production using T cell lines expressing chimeric T cell receptor genes. Eur J Immunol. 1995; 25:2985–2991.

    Article  PubMed  CAS  Google Scholar 

  65. Bousquet J, Lockey R, Mailing HJ, and the WHO panel members. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position. J Allergy Clin Immunol. 1998; 102:558–562.

    Article  PubMed  CAS  Google Scholar 

  66. Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, Swain SL, Spiegelberg HL, Carson DA. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA. 1996; 93:5141–5145.

    Article  PubMed  CAS  Google Scholar 

  67. Hsu CH, Chua KY, Tao MH, Lai YL, Wu HD, Huang SK, Hsieh KH. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nature Med. 1996; 2:540–544.

    Article  PubMed  CAS  Google Scholar 

  68. Haak-Frendscho M, Marsters SA, Mordenti J, Brady S, Gillett NA, Chen SA, Ashkenazi A. Inhibition of TNF by a TNF receptor immunoadhesin. Comparison to an anti-TNF monoclonal antibody. J Immunol. 1994; 152:1347–1351.

    PubMed  CAS  Google Scholar 

  69. Mullarkey MF, Leiferman KM, Peters MS, Caro I, Roux ER, Hanna RK, Rubin AS, Jacobs CA. Human cutaneous allergic late-phase response is inhibited by soluble IL-1 receptor. J Immunol. 1994; 152:2033–2041.

    PubMed  CAS  Google Scholar 

  70. Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, Romagnani S. Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med. 1993; 177:1199–1204.

    Article  PubMed  CAS  Google Scholar 

  71. Hogan SP, Foster PS, Tan X, Ramsay AJ. Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity. Eur J Immunol. 1998; 28:413–23.

    Article  PubMed  Google Scholar 

  72. Yssel H, Groux H. Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic diseases. Int Arch Allergy Immunol. 2000; 121°:10–18.

    Article  PubMed  Google Scholar 

  73. Stampfli MR, Cwiartka M, Gajewska BU, Alvarez D, Ritz SA, Inman MD, Xing Z, Jordana M. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Am J Respir Cell Mol Biol. 1999; 21:586–596.

    PubMed  CAS  Google Scholar 

  74. Hansen G, Mclntire JJ, Yeung VP, Berry G, Thorbecke GJ, Chen L, DeKruyff RH, Umetsu DT. CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest. 2000; 105:61–70.

    Article  PubMed  CAS  Google Scholar 

  75. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fails to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest. 1999; 103°: 175–183.

    Article  PubMed  Google Scholar 

  76. Nyce JW, Metzger WJ. DNA antisense therapy for asthma in an animal model. Nature. 1997; 385:721–725.

    Article  PubMed  CAS  Google Scholar 

  77. Gronemeyer H. Control of transcription activation by GC hormone receptors. FASEBJ. 1992;6:2524–2529.

    CAS  Google Scholar 

  78. Mathieu M, Gougat C, Jaffuel D, Danielsen M, Godard P, Bousquet J, Demoly P. The glucocorticoid receptor gene as a candidate for gene therapy in asthma. Gene Ther. 1999; 6:245–252.

    Article  PubMed  CAS  Google Scholar 

  79. Metz R, Kouzarides T, Bravo R. A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding ptotein, is required for altered cell growth. EMBO J 1994; 13:3832–3842.

    PubMed  CAS  Google Scholar 

  80. Baeuerle P, Baltimore D. A 65-kD subunit of active NF-κB is required for inhibition of NF-κB by IκB. Genes Dev. 1989; 3:1689–1698.

    Article  PubMed  CAS  Google Scholar 

  81. Alton EW, Griesenbach U, Geddes DM. Gene therapy for asthma: inspired research or unnecessary effort? Gene Ther. 1999; 6:155–156.

    Article  PubMed  CAS  Google Scholar 

  82. Wrighton CJ, Hofer-Warbinek R, Moll T, Eytner R, Bach FH, de Martin R. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB. J Exp Med. 1996; 183:1013–1022.

    Article  PubMed  CAS  Google Scholar 

  83. Handel M, Watts C, deFazio A, Day R, Sutherland R. Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos. Proc Natl Acad Sci USA. 1995; 92:4497–4501.

    Article  PubMed  CAS  Google Scholar 

  84. Jeon KI, Jeong JY, Jue DM. Thiol-reactive metal compounds inhibit NF-kappaB activation by blocking IkappaB kinase. J Immunol. 2000; 164:5981–5989.

    PubMed  CAS  Google Scholar 

  85. Bernstein IL, Bernstein DI, Dubb JW, Faiferman I, Wallin B. A placebo-controlled multicenter study of auranofin in the treatment of patients with corticosteroid-dependent asthma. Auranofin Multicenter Drug Trial. J Allergy Clin Immunol. 1996; 98:317–324.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Montpellier, France

    Marc Mathieu Ph.D.

  2. INSERM U454, France

    Pascal Demoly M.D., Ph.D.

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Editors and Affiliations

  1. Pulmonary and Critical Care Medicine Evanston Northwestern Healthcare, USA

    Phillip Factor D.O., F.C.C.P.

  2. Northwestern University Medical School, USA

    Phillip Factor D.O., F.C.C.P.

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Mathieu, M., Demoly, P. (2001). Gene Therapy for Asthma. In: Factor, P. (eds) Gene Therapy for Acute and Acquired Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1667-5_7

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