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Cardiac Angiogenesis and Gene Therapy: A Strategy for Myocardial Revascularization

  • Todd K. Rosengart

Abstract

Therapeutic angiogenesis is a strategy whereby delivery of a growth factor or other mediator that induces angiogenesis (the formation of a new vasculature) is used to augment the native angiogenic process and enhance reperfusion of ischemic tissues (1, 4). Gene transfer is a means of achieving therapeutic angiogenesis, whereby the cDNA coding for specific angiogens, rather than the protein itself, is administered to tissues in which angiogenesis is desired (5, 7). This review will focus on therapeutic angiogenesis based on gene transfer strategies for provision of myocardial revascularization.

Keywords

Gene Therapy Therapeutic Angiogenesis Vascular Endothelial Growth Factor Family Fibroblast Growth Factor Family Angiogenic Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Todd K. Rosengart
    • 1
  1. 1.Division of Cardiothoracic SurgeryEvanston Northwestern Healthcare and Northwestern UniversityUSA

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