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The Use of Magnetic Resonance Imaging in Cardiac Transplantation Rejection

  • Todd M. Koelling

Abstract

Several attempts have been made to monitor cardiac allograft rejection usingnoninvasive imaging modalities. Previous efforts to employ noninvasive imaging tofollow transplant recipients for signs of rejection have included echocardiography,1antimyosin scintigraphy,2 anti-vascular adhesion molecule scintigraphy,3 and radiolabeled lymphocyte scintigraphy.4 Each method has shown to detect clinical or experimental allograft rejection, but evidence of adequate sensitivity and specificity existsto supplant endomyocardial biopsy has been lacking.

Keywords

Myocardial Blood Flow Acute Rejection Left Ventricular Mass Endomyocardial Biopsy Cardiac Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ciliberto GR, Mascarello M, Gronda E, Bonacina E, Anjos MC, Danzi G, et al. Acute rejectionafter heart transplantation: noninvasive echocardiographic evaluation. J Am Coll Cardiol 1994;23:1156–61.PubMedCrossRefGoogle Scholar
  2. 2...
    Hesse B, Mortensen SA, Folke M, Brodersen AK, Aldershvile J, Pettersson G. Ability of antimyosinscintigraphy monitoring to exclude acute rejection during the first year after heart transplantation. Journal of Heart & Lung Transplantation 1995;14:23–31.Google Scholar
  3. 3...
    Isobe M, Ohtani H, Yagita H, Okumura K, Strauss HW, Yazaki Y. Detection of cardiac rejection inmice by radioimmune scintigraphy using 123iodine-labeled anti-ICAM-1 monoclonal antibody. Acta Cardiol 1993;48:235–43.PubMedGoogle Scholar
  4. 4...
    Rubin PJ, Hartman JJ, Hasapes JP, Bakke JE, Bergmann SR. Detection of cardiac transplant rejec-tion with 111In-labeled lymphocytes and gamma scintigraphy. Circulation 1996;94:II298–303.Google Scholar
  5. 5...
    Fraser CD Jr, Chacko VP, Jacobus WE, Soulen RL, Hutchins GM, Reitz BA, et al. Metabolic changespreceding functional and morphologic indices of rejection in heterotopic cardiac allografts. A 31Pnuclear magnetic resonance study. Transplantation 1988;46:346–51.PubMedCrossRefGoogle Scholar
  6. 6...
    Herfkens RJ, Charles HC, Negro-Vilar R, van Trigt P. In vivo phosphorus-31 NMR spectroscopy ofhuman heart transplants (abstr). Society of Magnetic Resonance in Medicine 1988;827.Google Scholar
  7. 7...
    Evanochko WT, Bouchard A, Kirklin JK, Bourge RC, Luney D, Pohost GM. Detection of cardiactransplant rejection in patients by 31P NMR spectroscopy (abstract). Society of Magnetic Resonancein Medicine 1990;246.Google Scholar
  8. 8...
    Gill EA, Borrego C, Bray BE, Renlund DG, Hammond EH, Gilbert EM. Left ventricular massincreases during cardiac allograft vascular rejection. J Am Coll Cardiol 1995;25:922–6.PubMedCrossRefGoogle Scholar
  9. 9...
    Florentine MS, Grosskreutz CL, Chang W, Hartnett JA, Dunn VD, Ehrhardt JC, et al. Measurementof left ventricular mass in vivo using gated nuclear magnetic resonance imaging. J Am Coll Cardiol1986;8:107–12.PubMedCrossRefGoogle Scholar
  10. 10...
    Caputo GR, Tscholakoff D, Sechtem U, Higgins CB. Measurement of canine left ventricular massby using MR imaging. American Journal of Roentgenology 1987;148:33–8.PubMedGoogle Scholar
  11. 11...
    Forbat SM, Karwatowski SP, Gatehouse PD, Firmin DN, Longmore DB, Underwood SR. Technicalnote: rapid measurement of left ventricular mass by spin echo magnetic resonance imaging. Br JRadiol 1994;67:86–90.CrossRefGoogle Scholar
  12. 12...
    Bottini PB, Carr AA, Prisant LM, Flickinger FW, Allison JD, Gottdiener JS. Magnetic resonanceimaging compared to echocardiography to assess left ventricular mass in the hypertensive patient. Am J Hypertens 1995;8:221–8.PubMedCrossRefGoogle Scholar
  13. 13...
    Revel D, Chapelon C, Mathieu D, Cochet P, Ninet J, Chuzel M, et al. Magnetic resonance imagingof human orthotopic heart transplantation: correlation with endomyocardial biopsy. Journal of HeartTransplantation 1989;8:139–46.Google Scholar
  14. 14...
    Wisenberg G, Pflugfelder PW, Kostuk WJ, McKenzie FN, Prato FS. Diagnostic applicability ofmagnetic resonance imaging in assessing human cardiac allograft rejection. Am J Cardiol 1987;60:130–6.PubMedCrossRefGoogle Scholar
  15. 14a...
    Marie PY, Angioi M, Carteaux JP et al. Detection and prediction of acute heart transplant rejectionwith the myocardial T2 determination provided by a black-blood magnetic resonance imagingsequence. J Am Coll Cardiol 2001;37:825–831.PubMedCrossRefGoogle Scholar
  16. 15...
    Tscholakoff D, Aherne T, Yee ES, Derugin N, Higgins CB. Cardiac transplantations in dogs:evaluation with MR. Radiology 1985;157:697–702.PubMedGoogle Scholar
  17. 16...
    Huber DJ, Kirkman RL, Kupiec-Weglinski JW, Araujo JL, Tilney NL, Adams DF. The detection ofcardiac allograft rejection by alterations in proton NMR relaxation times. Invest Radiol1985;20:796–802.PubMedCrossRefGoogle Scholar
  18. 17...
    Walpoth BH, Lazeyras F, Tschopp A, Schaffher T, Althaus U, Billingham M, et al. Assessment ofcardiac rejection and immunosuppression by magnetic resonance imaging and spectroscopy. Transplant Proc 1995;27:2088–91.PubMedGoogle Scholar
  19. 18...
    Aherne T, Tscholakoff D, Finkbeiner W, Sechtem U, Derugin N, Yee E, et al. Magnetic resonanceimaging of cardiac transplants: the evaluation of rejection of cardiac allografts with and withoutimmunosuppression. Circulation 1986;74:145–56.PubMedCrossRefGoogle Scholar
  20. 19...
    Kurland RJ, West J, Kelley S, Shoop JD, Harris R, Carr EA Jr, et al. Magnetic resonance imagingto detect heart transplant rejection: sensitivity and specificity. Transplant Proc 1989;21:2537–43.PubMedGoogle Scholar
  21. 20...
    Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, et al. Nuclear magneticresonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol 1983;52:184–8.PubMedCrossRefGoogle Scholar
  22. 21...
    Chan SY, Kobashigawa J, Stevenson LW, Brownfield E, Brunken RC, Schelbert HR. Myocardialblood flow at rest and during pharmacological vasodilation in cardiac transplants during and aftersuccessful treatment of rejection. Circulation 1994;90:204–12.PubMedCrossRefGoogle Scholar
  23. 22...
    Kaul SMD, Senior RMD MRCP, Dittrich HMD, RavalUsha BS, Khattar RMD, Lahiri AMD MRCP. Detection of coronary artery disease with myocardial contrast echocardiography: comparison withsup 99 m Tc-sestamibi single-photon emission computed tomography. Circulation 1997;96:785–92.PubMedCrossRefGoogle Scholar
  24. 23...
    Hundley WG, Lange RA, Clarke GD, Meshack BM, Payne J, Landau C, et al. Assessment of coronary arterial flow and flow reserve in humans with magnetic resonance imaging. Circulation1996;93:1502–8.PubMedCrossRefGoogle Scholar
  25. 24...
    Clarke GD, Eckels R, Chaney C, Smith D, Dittrich J, Hundley WG, et al. Measurement of absoluteepicardial coronary artery flow and flow reserve with breath-hold cine phase-contrast magneticresonance imaging. Circulation 1995;91:2627–34.PubMedCrossRefGoogle Scholar
  26. 25...
    Sakuma H, Saeed M, Takeda K, Wendland MF, Schwitter J, Szolar DH, et al. Quantification of coronary artery volume flow rate using fast velocity-encoded cine MR imaging. American Journal ofRoentgenology 1997;168:1363–7.Google Scholar
  27. 26...
    Arteaga C, Canet E, Ovize M, Janier M, Revel D. Myocardial perfusion assessed by subsecond magnetic resonance imaging with a paramagnetic macromolecular contrast agent. Invest Radiol 1994;29 Suppl 2:S54–7.PubMedCrossRefGoogle Scholar
  28. 27...
    Larsson HB, Fritz-Hansen T, Rostrup E, Sondergaard L, Ring P, Henriksen O. Myocardial perfusion modeling using MRI. Magn Reson Med 1996;35:716–26PubMedCrossRefGoogle Scholar
  29. 28...
    Jerosch-Herold M, Wilke N, Wang Y, Huang Y, Christensen B, Wilson RF, et al. MR first pass measurement of myocardial perfusion reserve in patients. (Abstract). International Society of MagneticResonance in Medicine 1997;22:476.Google Scholar
  30. 29...
    Atalay MK, Forder JR, Chacko VP, Kawamoto S, Zerhouni EA. Oxygenation in the rabbitmyocardium: assessment with susceptibility-dependent MR imaging. Radiology 1993; 189:759–64.PubMedGoogle Scholar
  31. 30...
    Niemi P, Poncelet BP, Kwong KK, Weisskoff RM, Rosen BR, Brady TJ, et al. Myocardial intensitychanges associated with flow stimulation in blood oxygenation sensitive magnetic resonanceimaging. Magn Reson Med 1996;36:78–82.PubMedCrossRefGoogle Scholar
  32. 31...
    Koelling TM, Poncelet BP, Schmidt CJ, Ledden P, Kwong KK, Reese TG, et al. Gradient-Echo EPIBOLD T2* contrast changes with varying doses of adenosine and correlation with coronary venousoxygen saturation in swine. (Abstract). International Society of Magnetic Resonance in Medicine1997;22:475.Google Scholar
  33. 32...
    Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, et al. Dynamicmagnetic resonance imaging of human brain activity during primary sensory stimulation. Proc NatlAcad Sci U S A 1992;89:5675–9.CrossRefGoogle Scholar
  34. 33...
    Poncelet BP, Koelling TM, Schmidt CJ, Ledden P, Kwong KK, Reese TG, et al. In vivo measurement of human myocardial tissue perfusion at rest and during hyperemia by double gated flow alternated inversion recovery EPI. Proceedings of the 5th Annual Meeting of the International Societyof Magnetic Resonance in Medicine 1997;22:88.Google Scholar
  35. 34...
    Bottomley PA. Noninvasive study of high-energy phosphate metabolism in human heart bydept-resolved 31P NMR spectroscopy. Science 1985;229:769–72.PubMedCrossRefGoogle Scholar
  36. 35...
    Ingwall JS, Kramer MF, Fifer MA, et al. The creatine kinase system in normal and diseased humanmyocardium. N Engl J Med 1985;313:1050–4.PubMedCrossRefGoogle Scholar
  37. 36...
    Fraser CD Jr, Chacko VP, Jacobus WE, Hutchins GM, Glickson J, Reitz BA, et al. Evidence from31P nuclear magnetic resonance studies of cardiac allografts that early rejection is characterized byreversible biochemical changes. Transplantation 1989;48:1068–70.PubMedCrossRefGoogle Scholar
  38. 37...
    Fraser CD Jr, Chacko VP, Jacobus WE, Mueller P, Soulen RL, Hutchins GM, et al. Early phosphorus 31 nuclear magnetic resonance bioenergetic changes potentially predict rejection in heterotopic cardiac allografts. Journal of Heart Transplantation 1990;9:197–204.PubMedGoogle Scholar
  39. 38...
    Wolfe CL, Caputo G, Chew W. Detection of cardiac transplant rejection by magnetic resonanceimaging and spectroscopy (abstract). Society of Magnetic Resonance in Medicine 1991;574.Google Scholar
  40. 39...
    Bottomley PA, Weiss RG, Hardy CJ, Baumgartner WA. Myocardial high-energy phosphate metabolism and allograft rejection in patients with heart transplants. Radiology 1991;181:67–75.PubMedGoogle Scholar
  41. 40...
    Bottomley PA. MR spectroscopy of the human heart: the status and the challenges. [Review].Radiology 1994;191:593–612PubMedGoogle Scholar
  42. 41...
    Malloy CR, Buster DC, Castro MMCA, Geraldes CFGC, Jeffrey FMH, Sherry AD. Influence ofglobal ischemia on intracellular sodium in the perfused rat heart. Magn Reson Med 1990;15:33–4.PubMedCrossRefGoogle Scholar
  43. 42...
    Waldrop SM, Alexander DZ, Lowry R, Winn KJ, Pearson TC, Constantinidis I. Analysis of allogeneicCrossRefGoogle Scholar
  44. 43...
    Eugene M, Le Moyec L, de Certaines J, Desruennes M, Le Rumeur E, Fraysse JB, et al. Lipoproteins in heart transplantation: proton magnetic resonance spectroscopy of plasma. Magn Reson Med1991;18:93–101.PubMedCrossRefGoogle Scholar
  45. 44...
    Le Floch M, Ramee MP, LeLong B, Leray G, Kerbaol M, de Certaines JD. Proton magneticresonance spectroscopy of blood plasma in heart transplant recipients treated with cyclosporine: anearly prognosis test of long-term graft tolerance. Journal of Heart & Lung Transplantation 1997; 16:381–6.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Todd M. Koelling
    • 1
  1. 1.Division of CardiologyUniversity of Michigan Medical CenterAnn ArborUSA

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