Selenium pp 219-233 | Cite as

Selenium deficiency and human disease

  • Ruth J. Coppinger
  • Alan M. Diamond

Abstract

The beneficial role of selenium became apparent in the 1950’s, when it was shown to prevent a variety of diseases in animals, often when these animals were already exhibiting vitamin E deficiency. In humans, there are several examples of disease that can be attributed to selenium deficiency, and for some, the ultimate causal relationship has been established by the demonstration that symptoms can be alleviated with selenium supplementation of the at risk population. This is true both in cases where diseases associated with selenium deficiency are endemic in areas of low selenium consumption, such as Keshan disease, Keshin-Beck disease and myxedematous cretinism, as well as in circumstances where selenium deficiency results from other pre-existing health conditions. The consequences of too little dietary selenium can be considered in the context of the decline of specific selenium-containing proteins, many of which have only recently been identified.

Keywords

Codon Aldehyde Pancreatitis Lysine Neurol 

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References

  1. 1.
    DG Barceloux 1999 Clin Toxicol 37:145CrossRefGoogle Scholar
  2. 2.
    JE Spallholz 1997 Biomed Environ Sci 10:260Google Scholar
  3. 3.
    ZJ Maksimovic, I Djujic 1997 Biomed Environ Sci 10:300Google Scholar
  4. 2.
    K Ge, G Yang 1993 Am J Clin Nutr Supp 57:259SGoogle Scholar
  5. 3.
    RD Utiger 1998 N Eng J Med 339:1156CrossRefGoogle Scholar
  6. 4.
    JR Arthur, GJ Beckett 1999 Brit Med Bull 55:658CrossRefGoogle Scholar
  7. 5.
    JB Vanderpas, B Contempre, NL Duale, W Goossens, N Bebe, R Thorpe, K Ntambue, Ch Thilly, AT Diplock 1990 Am Journal Clin Nutr 52:1087Google Scholar
  8. 6.
    JB Vanderpas, B Contempre, NL Duale, H Deckx, N Bebe, AO Longombe, CH Thilly, AT Diplock, JE Dumont 1993 Am J Clin Nutr Supp; 57:271 SGoogle Scholar
  9. 7.
    JE Dumont, AM Ermans, PA Bastenie 1963 J Clin Edocrinol Metab 23:325CrossRefGoogle Scholar
  10. 8.
    HJ Andersen 1961 Acta Pediatrica 50:Supp 125.CrossRefGoogle Scholar
  11. 9.
    JE Dumont, B Corvilain, B Contempre 1994 Mol Cell Endocrinol 100:163CrossRefGoogle Scholar
  12. 10.
    W Croteau, JC Davey, VA Galton, DL St Germain 1996 Journal of Clin Invest 98:405CrossRefGoogle Scholar
  13. 11.
    D St. Germain, VA Galton 1997 Thyroid 7:655CrossRefGoogle Scholar
  14. 12.
    JM Bates, VL Spate, JS Morris, DL St. Germain, VA Galton, 2000 Endocrinology 141:2490CrossRefGoogle Scholar
  15. 13.
    TD Buckman, MS Sutphin, CD Eckhert 1993 Biochem et Biophys Acta 1163:176CrossRefGoogle Scholar
  16. 14.
    B Contempre, JF Denef, JE Dumont, MC Many 1993 Endocrinology 132:1866CrossRefGoogle Scholar
  17. 15.
    B Contempre, JE Dumont, JF Denef, MC Many 1995 Eur J Endocrinol 133:99CrossRefGoogle Scholar
  18. 16.
    B Corvilain, B Contempré, AO Longombé, P Goyens, C Gervy-Decoster, F Lamy, JB Vanderpas, JE Dumont 1993 Am J Clin Nutr Suppl 57:244SGoogle Scholar
  19. 17.
    WH Yu 1982 Jap Circ J 46:1201CrossRefGoogle Scholar
  20. 18.
    OA Levander, MA Beck 1997 Biol Trace Elem Res 56:5.CrossRefGoogle Scholar
  21. 19.
    YY Cheng, PC Qian 1990 Biomed Environ Sci 3:422Google Scholar
  22. 20.
    VJ Ferrans 1989 Am J Cardio 64:9CCrossRefGoogle Scholar
  23. 21.
    Y Li, T Peng, Y Yang, C Niu, LC Archard, H Zhang 2000 Heart: 83:696CrossRefGoogle Scholar
  24. 22.
    A Aro, J Kumpulainen, G Alfthan, AV Voshchenko, VN Ivanov 1994 Biol Trace Element Res 40:277CrossRefGoogle Scholar
  25. 23.
    C Chai, J Tian, Q Qian, P Zhang, Q Xu, D Mao 1994 Biol Trace Element Res; 43-45:177CrossRefGoogle Scholar
  26. 24.
    Keshan Disease Research Group of the Chinese Academy of Medical Sciences 1979 Chinese Med J 92:477Google Scholar
  27. 25.
    R Moreno-Reyes, C Suetens, F Mathieu, F Begaux, D Zhu, M Rivera, M Boelaert, J Nève, N Perlmutter, J Vanderpas 1998 N Engl J Med 339:1112CrossRefGoogle Scholar
  28. 26.
    A Peng, C Yang, H Rui H Li 1992 J Toxicol Environ Health 35:79CrossRefGoogle Scholar
  29. 27.
    E Allander 1994 Scand J Rheum 23(Supp 99):1CrossRefGoogle Scholar
  30. 28.
    R Tomlinson, 1999 BMJ 318:485CrossRefGoogle Scholar
  31. 29.
    Y Wang, Zyang, L Gilula, C Zhu 1996 Radiology 201:265Google Scholar
  32. 30.
    J Vaughan 1981 The Physiology of Bone, Third Edition Clarendon Press, OxfordGoogle Scholar
  33. 31.
    C Yang, C Niu, M Bodo, E Gabriel, H Notbohm, E Wolf, P Müller 1993 Biochem J 289:829Google Scholar
  34. 32.
    FD Liu, ZL Wang, M Hinsenkamp 1998 I Orthopaedics 22:87CrossRefGoogle Scholar
  35. 33.
    C Yang, E Wolf, K Röser, G Delling, PK Müller 1993 Virchows Archiv A Pathol Anat Histopath 423:83Google Scholar
  36. 34.
    R Hartenstein 1981 Science 212:743CrossRefGoogle Scholar
  37. 35.
    A Peng, WH Wang, CX Wang, ZJ Wang, HF Rui, WZ Wang, ZW Yang 1999 Envirn Health Perspect 107:293CrossRefGoogle Scholar
  38. 36.
    C Chasseur, C Suetens, N Norland, F Bagaux, E Haubruge 1997 Lancet 350:1074CrossRefGoogle Scholar
  39. 39.
    RW Marcus 1993 MD Med 742:669Google Scholar
  40. 40.
    JB Levy, HW Jones, AC Gordon 1994 Prostgrad Med J 70:235CrossRefGoogle Scholar
  41. 41.
    CK Abrams, SM Siram, C Galsim, H Johnson-Hamilton, FL Munford, H Mezghebe 1992 Nutr Clin Pract 7:175CrossRefGoogle Scholar
  42. 42.
    M Yagi, T Tani, T Hashimoto, K Shimuzu, T Hagakawa, K. Miwa, I Miyazaki 1996 Nutrition 12:40CrossRefGoogle Scholar
  43. 43.
    AL Buchman, A. Moukarzal, ME Ament 1994 JPEN J Parenter Enterai Nutr 18:231CrossRefGoogle Scholar
  44. 44.
    Y Saito, T Hashimoto, M Sasaki, S Hanaoka, K Sugai 1998 Dev Med Child Neurol 40:743CrossRefGoogle Scholar
  45. 45.
    G Darling, P Mathias, M O’regan, E Naughten 1992 J Inherit Metab Dis 15:769CrossRefGoogle Scholar
  46. 46.
    TH Best, DN Franz, DL Gilbert, DP Nelson, MR Epstein 2000 Neurology 54:2328CrossRefGoogle Scholar
  47. 47.
    MM van Bakel, G Printzen, B Wermuth, UN Wiesmann 2000 Am J Clin Nutr 72:976Google Scholar
  48. 48.
    T Rannem, K Ladefoged, E Hylander, J Hegnoj, S. Jarnurn 1992 Am J Clin Nutr 56:933Google Scholar
  49. 49.
    T Zima, VT Tesar, O Mestek, K Nemecek 1999 Blood Purification 17:187CrossRefGoogle Scholar
  50. 50.
    DJ Bowrey, GJ Morris-Stiff, MC Puntis 1999 HPB Surg 11:207CrossRefGoogle Scholar
  51. 51.
    X Forceville, D. Vitoux, R Gauzit, A Combes, P Lahilaire, P Chappuis 1998 Crit Care Med 26:1536CrossRefGoogle Scholar
  52. 52.
    R Gartner, M Angstwurm 1999 Med Klin 94Suppl 3:54CrossRefGoogle Scholar
  53. 53.
    VT Ramaekers, M Calomme, D Vanden Berghe, W Makropoulos 1994 Neuropediatrics 25:217CrossRefGoogle Scholar
  54. 54.
    BA Darlow, TE Inder, PJ Graham, KB Sluis, TJ Malpas, BJ Taylor, Winterbourn 1995 Pediatrics 96:314Google Scholar
  55. 55.
    JW Barrington, P Lindsay, D James, S Smith, A Roberts 1996 Br J Obstet Gynaecol 103:130CrossRefGoogle Scholar
  56. 56.
    MP Rayman 2000 Lancet 356:233CrossRefGoogle Scholar
  57. 57.
    M-C Toufektsian, F Boucher, S Pucheu, S Tanguy, C Ribout, D Sanou, Tresallet, J de Leiris 2000 Toxicol 148:125CrossRefGoogle Scholar
  58. 58.
    MK Baum, G Shor-Posner, L Shenghan, Z Guoyan, L Hong, MA Fletcher, H Sauberlich, JB Page 1997 J Acquir Immune Defic Syndrom Human Retrovirol 15:370CrossRefGoogle Scholar
  59. 59.
    ME Moustafa, MA El-Saadani, KM Kandeel, DB Mansur, BJ Lee, DL Hatfield, AM Diamond 1998 RNA 4:1CrossRefGoogle Scholar
  60. 60.
    MS Saedi, CG Smith, J Frampton, I Chambers, PR Harrison, RA Sunde 1988 Biochem Biophys Res Commun 153:855CrossRefGoogle Scholar
  61. 61.
    G Bermano, F Nicol, JA Dyer, RA Sunde, GJ Beckett, JR Arthur, JE Hesketh 1995 Biochem J 311(pt 2):425Google Scholar
  62. 62.
    PM Moriarty, CC Reddy, LE Maquat 1998 Mol Cell Biol 18:2932Google Scholar
  63. 63.
    VN Gladyshev, DL Hatfield 1999 J Biomed Sci 6:151CrossRefGoogle Scholar
  64. 64.
    Y Kayanoki, J Fuji, KN Islam, K Suzuki, S Kawata, Y Matsuzawa, N Taniguchi 1996 J Biochem (Tokyo) 119:817CrossRefGoogle Scholar
  65. 65.
    JL Shisler, TG Senkevich, MJ Berry, B Moss 1998 Science 279:102CrossRefGoogle Scholar
  66. 66.
    DM Hockenbery, ZN Oltavi, X-M Yin, CL Millman, SJ Korsmeyer 1993 Cell 75:241CrossRefGoogle Scholar
  67. 67.
    PA Sandstrom, J Murray, TM Folks, AM Diamond 1998 Free Rad Biol Med 24:1485CrossRefGoogle Scholar
  68. 68.
    V Adler, Z Yin, KD Tew, Z Ronai 1999 Oncogene 18:6104CrossRefGoogle Scholar
  69. 69.
    K Nomura, H Imai, T Koumura, M Arai, Y Nakagawa 1999 J Biol Chem 274:29294CrossRefGoogle Scholar
  70. 70.
    H-S Park, S-H Huh, Y Kim, J Shim, S-H Lee, I-S Park, Y-K Jung, IY Kim, E-J Choi 2000 J Biol Chem 275:8487CrossRefGoogle Scholar
  71. 71.
    R Brigelius-Flohe, R Maurer, K Lotzer, G Bol, H Kallionpaa, P Lehtolainen, H Viita, S Yla-Herttuala 2000 Atherosclerosis 152:307CrossRefGoogle Scholar
  72. 72.
    C Kretz-Remy, P Mehlen, ME Mirault, AP Arrigo 1996 J Cell Biol 133:1083CrossRefGoogle Scholar
  73. 73.
    V Adler, MR Pincus, S Posner, P Upadhayaya, K El-Bayoumy, Z Ronai 1996 Carcin 17:1849CrossRefGoogle Scholar
  74. 74.
    SR Stapelton, GL Garlock, L Foellmi-Adams, RF Kletzien 1997 Biochem Biophys Acta 1355:259CrossRefGoogle Scholar
  75. 75.
    YJ Hei, S Farahbakhshian, X Chen, ML Batteil, JH McNeil 1998 Mol Cell Biochem 178:367CrossRefGoogle Scholar
  76. 76.
    SM Shieke, K Briviba, LO Klotz, H Sies 1999 FEBS Lett 448:301CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Ruth J. Coppinger
    • 1
  • Alan M. Diamond
    • 1
  1. 1.Department of Human NutritionUniversity of Illinois at ChicagoChicagoUSA

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