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Combined Modality Therapy for Early Stage Operable and Locally Advanced Potentially Resectable Non-Small Cell Lung Carcinoma

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Thoracic Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 105))

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Abstract

Surgical resection of non-small cell lung carcinoma (NSCLC) remains the primary treatment for early stage disease, that is, stage I and II disease. Yet, the vast majority of patients with lung cancer present with either distant metastatic disease (stage IV) or locally advanced NSCLC (stage IIIA and IIIB). Today, despite modest gains in outcome in patients with early stage disease, using improved surgical techniques, better preoperative risk assessment, and advances in thoracic anesthesia, a significant proportion of these patients will eventually succumb to their disease due to local and/or distant recurrence. For those patients with locally advanced NSCLC, defined either by the presence of mediastinal nodal involvement or a primary tumor that invades key thoracic elements (chest wall, vertebral body, great vessels) surgical resection of this tumor is either difficult (T3) or impossible (T4). Therefore, a combined modality approach to the treatment of most operable or potentially resectable non-small cell lung cancers has been actively pursued by clinical investigators.

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  1. Loyola University Medical Center, Maywood, IL, 60153, USA

    Joseph I. Clark MD & Kathy S. Albain MD

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  1. The Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, Baltimore, Maryland, USA

    David S. Ettinger MD

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Clark, J.I., Albain, K.S. (2001). Combined Modality Therapy for Early Stage Operable and Locally Advanced Potentially Resectable Non-Small Cell Lung Carcinoma. In: Ettinger, D.S. (eds) Thoracic Oncology. Cancer Treatment and Research, vol 105. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1589-0_6

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