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Impact of Genomic Variations on Inflammatory Processes and Sepsis

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Evolving Concepts in Sepsis and Septic Shock

Part of the book series: Perspectives on Critical Care Infectious Diseases ((CCID,volume 2))

Abstract

The immune response to injury involves a complex pattern of primary, secondary and tertiary humoral and cellular responses. Genetic variability in the expression of the mediators comprising these responses constitutes the genetic background which may potentially influence the course of inflammation in each individual. Differences in this background may in part explain the highly variable clinical courses noted among septic patients. Comparable doses of infecting microbes may induce a wide range of severity of illness due in part to genetic variability.

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Authors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, University of Bonn, Bonn, Germany

    Frank Stüber M.D.

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  1. Frank Stüber M.D.
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Editors and Affiliations

  1. Critical Care Medicine Department, Warren Grant Magnuson Clinical Center National Institutes of Health, 10 Center Drive Building 10, Room 7D43, Bethesda, MD, 20892, USA

    Peter Q. Eichacker M.D.

  2. Division of Medical Intensive Care, University Hospital of Geneva, CH-1211, Geneva 14, Switzerland

    Jérôme Pugin M.D.

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Stüber, F. (2001). Impact of Genomic Variations on Inflammatory Processes and Sepsis. In: Eichacker, P.Q., Pugin, J. (eds) Evolving Concepts in Sepsis and Septic Shock. Perspectives on Critical Care Infectious Diseases, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1581-4_6

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  • DOI: https://doi.org/10.1007/978-1-4615-1581-4_6

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