Growth Hormone Treatment in Experimental Heart Failure

  • Jörgen Isgaard
  • Bengt-Åke Bengtsson
Part of the Endocrine Updates book series (ENDO, volume 9)


During the last years, GH and IGF-I have been recognized as important regulators of cardiac structure and function. The effects of GH on peripheral tissues are thought to be either direct or mediated by IGF-I. IGF-I is synthesized in multiple tissues including the heart and some of the effects have been suggested to be paracrine or autocrine (1-4). Both GH and IGF-I receptors are expressed in the heart and provide possibilities for GH and IGF-I signalling. Importance of the GH/IGF-I axis for the development of cardiac hypertrophy in response to increased hemodynamic load will be discussed in this chapter along with an overview of GH and IGF-I effects on intracellular calcium handling, apoptosis and cardiac performance in various experimental models.


Cardiac Hypertrophy Growth Hormone Treatment Experimental Myocardial Infarction Experimental Heart Failure Intracellular Calcium Handling 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Jörgen Isgaard
    • 1
  • Bengt-Åke Bengtsson
    • 1
  1. 1.Sahlgrenska University HospitalResearch Center for Endocrinology and MetabolismGöteborgSweden

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