Abstract
During the last years, GH and IGF-I have been recognized as important regulators of cardiac structure and function. The effects of GH on peripheral tissues are thought to be either direct or mediated by IGF-I. IGF-I is synthesized in multiple tissues including the heart and some of the effects have been suggested to be paracrine or autocrine (1-4). Both GH and IGF-I receptors are expressed in the heart and provide possibilities for GH and IGF-I signalling. Importance of the GH/IGF-I axis for the development of cardiac hypertrophy in response to increased hemodynamic load will be discussed in this chapter along with an overview of GH and IGF-I effects on intracellular calcium handling, apoptosis and cardiac performance in various experimental models.
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Isgaard, J., Bengtsson, BÅ. (2001). Growth Hormone Treatment in Experimental Heart Failure. In: Giustina, A., Manelli, F. (eds) Growth Hormone And The Heart. Endocrine Updates, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1579-1_9
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DOI: https://doi.org/10.1007/978-1-4615-1579-1_9
Publisher Name: Springer, Boston, MA
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