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Growth Hormone Treatment in Experimental Heart Failure

  • Jörgen Isgaard
  • Bengt-Åke Bengtsson
Part of the Endocrine Updates book series (ENDO, volume 9)

Abstract

During the last years, GH and IGF-I have been recognized as important regulators of cardiac structure and function. The effects of GH on peripheral tissues are thought to be either direct or mediated by IGF-I. IGF-I is synthesized in multiple tissues including the heart and some of the effects have been suggested to be paracrine or autocrine (1-4). Both GH and IGF-I receptors are expressed in the heart and provide possibilities for GH and IGF-I signalling. Importance of the GH/IGF-I axis for the development of cardiac hypertrophy in response to increased hemodynamic load will be discussed in this chapter along with an overview of GH and IGF-I effects on intracellular calcium handling, apoptosis and cardiac performance in various experimental models.

Keywords

Cardiac Hypertrophy Growth Hormone Treatment Experimental Myocardial Infarction Experimental Heart Failure Intracellular Calcium Handling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Jörgen Isgaard
    • 1
  • Bengt-Åke Bengtsson
    • 1
  1. 1.Sahlgrenska University HospitalResearch Center for Endocrinology and MetabolismGöteborgSweden

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