Role of Ran GTPase in RNA Processing and Export of RNA from the Nucleus to the Cytosol: Insights from Budding Yeast

  • Anita K. Hopper


The Ran GTPase functions directly in nucleus/cytosol exchange, microtubule and spindle assembly, and likely other processes. This chapter focuses on use of the budding yeast (Saccharomyces cerevisiae) model system to delineate the in vivo roles of the Ran pathway in the export of tRNAs, ribosomes, and mRNA from the nucleus to the cytosol. Emphasis is placed upon the complex multiple and overlapping pathways that exist and possible mechanisms by which the Ran cycle may respond to environmental cues to assure that nuclear/cytosol exchange is coordinated with cellular metabolism. The data support direct roles for Ran in tRNA and ribosome nuclear export, but it is not clear whether Ran functions directly in mRNA nuclear export.


Nuclear Export Nuclear Import mRNA Export Nuclear Interior Nuclear Export Sequence 
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Anita K. Hopper
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyPennsylvania State University, College of MedicineHersheyUSA

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