Studies on Chemical Components and their Pharmacological Activities of Panax Ginseng Root
This paper explains the details of how ginsenosides are isolated and extracted from the roots of Panax ginseng. Fresh ginseng homogenate and red ginseng powder were soaked with MeOH, which resulted in a concentrated extract. The extract was then diluted with water and Et2O was added. The water phase was further extracted by water-saturated n-BuOH, and the new extract was chromatography on Macro-reticular resin column. Water was used as elutriation to remove impurities, such as sugar and water-soluble substances, and the extract was further eluted with a different fraction of MeOH. Every part was chromatography on silica gel column, and the individual ginsenosides were isolated. The identity of these ginsenosides was obtained after hydrolysis, partial hydrolysis, methylation, permethylation, methanolysis, and acethylation. Various types and structures of the ginsenosides are included in this report. Finally, each ginsenoside was tested for relevant pharmacological action. The purpose of this paper is to provide a molecular basis for the many health benefits received by taking ginseng.
KeywordsSugar Hydrolysis Ischemia MeOH Et20
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- Fuli et al. Studies on anti-tumor mechanism of ginsenoside-Rg3, the second seminar of natural medicine resource, 1997, 5, 114.Google Scholar
- Kobashi Koyoichi, Ginsenoside metabolism in bowel and absorption. The Ginseng Review, No.26:P90–91.Google Scholar
- Li xianggao Studies on extraction and bioactivity of new components from ginseng, P135-P138, Jilin Agricultural University.Google Scholar
- Oura Hikokichi, Physiology and pharmacology activity of ginsenoside, The Ginseng Review, No. 26:P35, P50.Google Scholar
- Yangying et al., Discuss on Rb1 and Rg1 promote wise activity mechanism, ACTA PHARMACEUTICA SINICA, 1994, 29:P240.Google Scholar
- Zhang Juntian et al., Effect of Ginsenoide-Rg1 and Rb1 on center nerve system transmitter receiver and brain synthesis protein 1988, 32:P12.Google Scholar