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Immunomodulation of Cytokines in Experimental Models of Heart Failure

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Book cover The Role of Inflammatory Mediators in the Failing Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 236))

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Abstract

Congestive heart failure (CHF) may be produced by a variety of disorders, including dilated cardiomyopathy, hypertensive heart disease, and ischemic heart disease. We have developed experimental models of these diseases. In a murine model of myocarditis, inflammatory cytokines were induced rapidly in the myocardium, and remained expressed during the chronic stage, when the heart had developed the typical characteristics of dilated cardiomyopathy. In the pressure-overloaded ventricle, the myocardium developed adaptive hypertrophy before its transition to heart failure, a process in which cytokines appeared to play a significant role by accelerating myocyte growth and down-modulating cardiac function. In the ischemic heart, the non-ischemic myocardium developed hypertrophy associated with progression of scarring in the ischemic area. This remodeling process initially represents an important compensatory mechanism to preserve ventricular function, though later leads to the development of heart failure. During this phase of healing from acute ischemia, inflammatory cytokines were persistently upregulated in the non-ischemic myocardium. Thus, we hypothesized that some aspects of heart failure may be mediated by reversible alterations of cardiac function and structural changes in the ventricle induced by cytokines. In the respect, several drugs used routinely in clinical practice have been proved to modulate the production of cytokines, suggesting that immunomodulating or anticytokine therapy may represent a new approach to the management of heart failure [1].

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Author information

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, Kyoto, Japan

    Akira Matsumori MD, PhD & Shigetake Sasayama MD, PhD

Authors
  1. Akira Matsumori MD, PhD
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  2. Shigetake Sasayama MD, PhD
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Douglas L. Mann M.D. (Director, Winters Center for Heart Failure Research, Gordon Cain Chair and Professor of Medicine) (Director, Winters Center for Heart Failure Research, Gordon Cain Chair and Professor of Medicine)

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Matsumori, A., Sasayama, S. (2001). Immunomodulation of Cytokines in Experimental Models of Heart Failure. In: Mann, D.L. (eds) The Role of Inflammatory Mediators in the Failing Heart. Developments in Cardiovascular Medicine, vol 236. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1449-7_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1449-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5559-5

  • Online ISBN: 978-1-4615-1449-7

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