Prolactinomas and Pregnancy

  • Nina Rosa de Castro Musolino
  • Marcello Delano Bronstein
Part of the Endocrine Updates book series (ENDO, volume 15)


Pituitary tumors correspond to 10 to 15% of intracranial tumors and its prevalence reaches as much as 27% in autopsy studies of the population (1). These tumors may be classified as microadenomas (diameter <10 mm) and macroadenomas (>10 mm), and could be enclosed, expansive and/or invasive (2). Prolactin-secreting adenomas (prolactinomas) are the most common of the pituitary-secreting tumors, and its prevalence is estimated at 500 cases/1,000,000 inhabitants (3). The incidence of prolactinomas is four times greater in women than in men; the microadenomalmacroadenoma ratio is approximately 3:1 in women. Since hyperprolactinemia is usually associated with anovulation, and prolactinomas present a greater incidence in the 3rd and 4th decades, these tumors are an important cause of infertility. Its treatment very frequently restores the hypothalamus-pituitary-ovary axis and it is expected to result in pregnancies. This chapter addresses the management of pregnancy in patients with prolactinomas submitted to different treatments, assessing their results and the deleterious effects on mother and fetus.


Pituitary Adenoma Dopamine Agonist Prolactin Level Tumor Shrinkage Serum Prolactin Level 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Nina Rosa de Castro Musolino
    • 1
  • Marcello Delano Bronstein
    • 1
  1. 1.Neuroendocrine Unit, Hospital das ClinicasUniversity of S. Paulo Medical SchoolBrazil

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