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Molecular Biology of Acute Lung Injury pp 275–288Cite as

The Heat Shock Response and Heat Shock Protein 70: Cytoprotection in Acute Lung Injury

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Part of the book series: Molecular and Cellular Biology of Critical Care Medicine ((MCCM,volume 1))

Abstract

In 1962 Ferruccio Ritossa described a distinct, hyperthermia-dependent puffing pattern in the giant chromosomes from the salivary glands of Drosophila (1). Subsequent investigations linked this puffing pattern with the expression of a specific group of proteins that were fittingly named “heat shock proteins,” and the expression of these proteins in response to hyperthermia was termed the “heat shock response.” During the ensuing four decades the field of heat shock response biology has grown immensely and it has become evident that all organisms have the capacity to induce the heat shock response, which is now recognized as having fundamental importance in both cellular biology and medicine. One of the more important functional consequences of the heat shock response is its ability to confer cytoprotection against a variety of cellular and tissue injuries relevant to clinical medicine, including ischemia-reperfusion injury, inflammatory injury, and oxidant-mediated injury.

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  1. Division of Critical Care Medicine, Children’s Hospital Medical Center and Children’s Hospital Research Foundation, Cincinnati, OH, USA

    Hector R. Wong

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    Hector R. Wong  & Thomas P. Shanley  & 

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Wong, H.R. (2001). The Heat Shock Response and Heat Shock Protein 70: Cytoprotection in Acute Lung Injury. In: Wong, H.R., Shanley, T.P. (eds) Molecular Biology of Acute Lung Injury. Molecular and Cellular Biology of Critical Care Medicine, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1427-5_18

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