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Community Respiratory Viral Infections: An Overlooked Cause of Morbidity and Mortality in Transplant Recipients

  • Núria Rabella
Part of the Perspectives on Critical Care Infectious Diseases book series (CCID, volume 1)

Abstract

Acute respiratory tract infection is one of the most common human diseases. Viruses are far more frequent etiologic agents of these conditions than bacteria (1,2). Until recently, study of respiratory viruses was restricted to the pediatric population and the role of respiratory viruses in adults was overlooked.

Keywords

Influenza Virus Transplant Recipient Respiratory Syncytial Virus Acute Otitis Medium Respiratory Syncytial Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Monto AS, Napier JA,Metzner. The Tecumseh study of respiratory illness. I. Plan of study and observations on syndromes of acute respiratory disease. Amer J Epidem 1971; 94: 269–279.Google Scholar
  2. 2.
    Monto AS, Cavallaro JJ. The Tecumseh study of respiratory illness. II..Pattems of occcunence of infection with respiratory pathogens, 1965–1969. Amer J Epidem 1971; 94: 280–289.Google Scholar
  3. 3.
    Whimbey EE, Englund JA. Community respiratory virus infections in transplant recipients. In: Bowden RA, Ljungman P, Paya CV, eds. Transplant infections. Philadelphia: Lippincott-Raven Publishers, 1998; 295–308.Google Scholar
  4. 4.
    Englund JA, Sullivan CJ, Jordan C, Dehner LP, Vercellotti GM, Balfour HH. Respiratory syncytial virus infection in immunocompromised adults. Ann Intern Med 1988; 109: 203–208.PubMedCrossRefGoogle Scholar
  5. 5.
    Sinnott JT, Cullison JP, Sweeney MS, Hammond M, Holt DA. Respiratory syncytial virus pneumonia in a cardiac transplant recipient. J Infect Dis 1988; 158: 650–651.PubMedCrossRefGoogle Scholar
  6. 6.
    Hertz MI, Englund JA, Snover D, Bitterman PB, McGlave PB. Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: A clinical approach and review of the literature. Medicine 1989; 68: 269–281.PubMedCrossRefGoogle Scholar
  7. 7.
    Glezen WP, Couch RB. Influenza Viruses. In: Evans AS ed. Viral infections of humans. Epidemiology and control, 3rd ed. New York. Plenum Medical Book Company, 1989; 419–449.Google Scholar
  8. 8.
    Hierholzer JC. Adenovirus. In Schmidt NJ and Emmons RW. eds. Diagnostic procedures for viral, rickettsial and chlamidial infections. 6d’ ed. Washington. American Public Health Association 1989; 219–264.Google Scholar
  9. 9.
    Chonmaitree T, Mann L. Respiratory infections. In Rotbart HA. Human enterovirus infections. Washington D.C. ASM Press, 1995; 255–270.Google Scholar
  10. 10.
    González Y, Martino R, Badell I, et al. Pulmonary enterovirus infections in stem cell transplant recipients Bone Marrow Transplant 1999; 23: 511–513.Google Scholar
  11. 11.
    Cherry JD. Enteroviruses: Coxsackieviruses, Echoviruses, and Polioviruses. In Feigin RD and Cherry JD eds. Textbook of pediatric infectious diseases. 4d’ ed. Philadelphia. WB Saunders Company, 1998; 1787–1839.Google Scholar
  12. 12.
    Gwaltney JM. Rhinoviruses. In: A.S. Evans ed. Viral infections of humans. Epidemiology and control. 3rd ed. New York. Plenum Medical Book Company, 1989; 593–615.CrossRefGoogle Scholar
  13. 13.
    Macnaughton MR. Occurrence and frequency of coronavirus infections in humans as determined by enzyme-linked immunosorbent assay. Infect Immun 1982; 38: 419–423.PubMedGoogle Scholar
  14. 14.
    DeFabritus AM, Riggio RR, David DS, et al. Parainfluenza type 3 in a transplant unit. JAMA 1979; 241: 384–386.PubMedCrossRefGoogle Scholar
  15. 15.
    Wendt CH. Community respiratory viruses: organ transplant recipients. Am J Med 1997; 102 (3 A): 31–36.PubMedCrossRefGoogle Scholar
  16. 16.
    Mathur U, Bentley DW, Hall CB. Concurrent respiratory syncytial virus and influenza A infections in the institutionalized elderly and chronically ill. Ann Intern Med 1980; 93:49–52.PubMedCrossRefGoogle Scholar
  17. 17.
    Kellner G, Popow-Kraupp T, Kundi M, Binder C, Kunz C. Clinical manifestations of respiratory tract infections due to respiratory syncytial virus and rhinoviruses in hospitalized children. Acta Pediatr Scan 1989; 78: 390–394.CrossRefGoogle Scholar
  18. 18.
    Rabella N, Prats G. Respiratory tract infections of viral origin in immunocompetent patients. Clin Pulm Med 1999; 6: 9–17.CrossRefGoogle Scholar
  19. 19.
    Denny FW, Jr. The clinical impact of human respiratory virus infections. Am J Respir Crit Care Med 1995; 152: S4–S12.PubMedCrossRefGoogle Scholar
  20. 20.
    McIntosh K, Halonen P, Ruuskanen O. Report of a workshop on respiratory viral infections: epidemiology, diagnosis, treatment, and prevention. Clin Infec Dis 1993; 16: 151–164.CrossRefGoogle Scholar
  21. 21.
    GlezenWP. Viral pneumonia as a cause and result of hospitalization. J Infec Dis 1983; 147: 765–770.CrossRefGoogle Scholar
  22. 22.
    Waner JL. Mixed viral infections: detection and management. Clin Microbiol Rev 1994; 7: 143–151.PubMedGoogle Scholar
  23. 23.
    Drews AL, Atmar RL, Glezen WP, Baxter BD, Piedra PA, Greenberg SB. Dual respiratory virus infections. Clin Infect Dis 1997; 25: 1421–1429.PubMedCrossRefGoogle Scholar
  24. 24.
    Mims CA. The pathogenesis of infectious disease. 3d ed. London Academic Press, 1987.Google Scholar
  25. 25.
    Carson JL, Collier AM, Hu SS. Acquired ciliary defects in nasal epithelium of children with acute viral upper respiratory infections. N Engl J Med 1985; 312: 463468.Google Scholar
  26. 26.
    Bakaletz LO. Viral potentiation of bacterial superinfection of the respiratory tract. Trends Microbiol 1995; 3: 110–114.PubMedCrossRefGoogle Scholar
  27. 27.
    Saez-Llorens X. Pathogenesis of acute otitis media. Pediatr Infect Dis J 1994; 13: 1035–1038.PubMedGoogle Scholar
  28. 28.
    Influenza-the human disease. Stuart-Harris CH, Schild GC. Influenza. The viruses and the disease. London. Edward Arnold Ltd. 1976; 96–111Google Scholar
  29. 29.
    Eskola J, Hovi T. Respiratory viruses in acute otitis media. N Engl J Med 1999; 340: 312–313.PubMedCrossRefGoogle Scholar
  30. 30.
    Heikkinen T, Ruuskanen 0, Waris M, Ziegler T, Arola M, Halonen P. Influenza vaccination in the prevention of acute otitis media in children. Am J Dis Child 1991; 145: 445–448.PubMedGoogle Scholar
  31. 31.
    Bowden RA. Respiratory virus infections after marrow transplant: The Fred Hutchinson Cancer Research Center experience. Am J Med 1997; 102(3 A): 27–30.PubMedCrossRefGoogle Scholar
  32. 32.
    Raad I, Abbas J, Whimbey E. Infection Control of Nosocomial Respiratory Viral Disease in the Immunocompromised Host. Am J Med. 1997; 102(3A): 48–52.PubMedCrossRefGoogle Scholar
  33. 33.
    Hirschhorn LR, McIntosh K, Anderson KJ, Dermody TS. Influenzal pneumonia as a complication of autologous bone marrow transplantation. Clin Infect Dis 1992; 14: 786–787.PubMedCrossRefGoogle Scholar
  34. 34.
    Whimbey E, Vartivarian SE, Champlin RE, Elting LS, Luna M, Bodey GP. Parainfluenza virus infection in adult bone marrow transplant recipients. Eur J Clin Microbiol Infect Dis 1993; 12: 699–701.PubMedCrossRefGoogle Scholar
  35. 35.
    Whimbey E, Champlin RE, Couch RB, et al. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients. Clin Infect Dis 1996; 22: 778–782.PubMedCrossRefGoogle Scholar
  36. 36.
    Lewis VA, Champlin R, Englund J, et al. Respiratory disease due to parainfluenza virus in adult bone marrow transplant recipients. Clin Infect Dis 1996; 23: 10331037.Google Scholar
  37. 37.
    Markovic SN, Adlakha A, Smith TF, Walker RC. Respiratory syncytial virus pneumonitis-induced diffuse alveolar damage in an autologous bone marrow transplant recipient. Mayo Clin Proc 1998; 73: 153–156.PubMedCrossRefGoogle Scholar
  38. 38.
    Taylor CE, Osman HKE, Turner AJL, Flood TJ, Abinum M, Crooks B, Cant M. Parainfluenza virus and respiratory syncytial virus infection in infants undergoing bone marrow transplantation for severe combined immunodeficiency. Commun Dis Public Health 1998; 1: 202–203.PubMedGoogle Scholar
  39. 39.
    Ghosh S, Champlin R, Couch R, et al. Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients. Clin Infect Dis 1999; 29:528–532.PubMedCrossRefGoogle Scholar
  40. 40.
    Rabella N, Rodriguez P, Labeaga R, et al. Conventional respiratory viruses recovered from immunosuppressed patients. Clinical considerations. Clin Infect Dis 1999; 28: 1043–1048.PubMedCrossRefGoogle Scholar
  41. 41.
    González Y, Martino R, Rabella N, Labeaga R, Badell I, Sierra J. Community respiratory virus infections in patients with hematological malignancies. Haematologica 1999; 84: 820–823.PubMedGoogle Scholar
  42. 42.
    McColl MD, Corser RB, Bremner J, Chopra R. Respiratory syncytial virus infection in adult BMT recipients: effective therapy with short duration nebulised ribavirin. Bone Marrow Transplant 1998; 21: 423–425.PubMedCrossRefGoogle Scholar
  43. 43.
    Lewinsohn DM, Bowden RA, Mattson D, Crawford SW. Phase I study of intravenous ribavirin treatment of respiratory syncytial virus pneumonia after bone marrow transplantation. Antimicrob Agents Chemother 1996; 40: 2555–2557.PubMedGoogle Scholar
  44. 44.
    Whimbey E, Champlin RE, Englund JA, et al. Combination therapy with aerosolized ribavirin and intravenous immunoglobulin for respiratory syncytial virus disease in adult bone marrow transplant recipients. Bone Marrow Transplant 1995; 16: 393–399.PubMedGoogle Scholar
  45. 45.
    Liles WC, Cushing H, Holt S, Bryan C, Hackman RC. Severe adenoviral nephritis following bone marrow transplant: succesful treatment with intravenous ribavirin. Bone Marrow Transplant 1993; 12: 409–412.PubMedGoogle Scholar
  46. 46.
    Ribaud P, Scieux C, Freymuth F, Morinet F, Gluckman E. Successful treatment of adenovirus disease with intravenous cidofovir in an unrelated stem-cell transplant recipient.Google Scholar
  47. 47.
    CDC Guidelines for prevention of nosocomial pneumonia. MMWR 1997; 46.Google Scholar
  48. 48.
    Bartlett JG, Breiman RF, Mandell LA, File TM. Community-acquired pneumonia in adults: guidelines for management. Clin Infect Dis 1998; 26: 811–838.PubMedCrossRefGoogle Scholar
  49. 49.
    Carrigan DR. Adenovirus infections in immunocompromised patients. Am J Med 1997;102(3 A):71–74.PubMedCrossRefGoogle Scholar
  50. 50.
    Michaels MG, Green M, Wald ER, Starzl TE. Adenovirus infection in pediatric liver transplant recipients. J Infec Dis 1992; 165: 170–174.CrossRefGoogle Scholar
  51. 51.
    Hierholzer JC. Adenoviruses in the immunocompro-mised host. Clin Microbiol Rev 1992; 5:262–274.PubMedGoogle Scholar
  52. 52.
    Hall CB, Douglas RG, Jr. Clinically useful method for the isolation of respiratory syncytial virus. J Infect Dis 1975; 131: 1–5.PubMedCrossRefGoogle Scholar
  53. 53.
    Landry M L, Cohen S, Ferguson D. Impact of Sample Type on Rapid Detection of Influenza Virus A by Cytospin-Enhanced Immunofluorescence and Membrane Enzyme-Linked Immunosorbent Assay. Journal of Microbiology 2000; 429–430.Google Scholar
  54. 54.
    Greenberg SB, Krilov LR. Cumitech 21. Laboratory diagnosis of viral respiratory disease. Coordinating ed., WL Drew, SJ Rubin. American Society for Microbiology, Washington, D.C. 1986.Google Scholar
  55. 55.
    Baxter BD, Couch RB, Greenberg SD, Kasel JA. Maintenance of viability and comparison of identification methods for influenza and other respiratory viruses of humans. J Clin Microbiol 1977; 6: 19–22.PubMedGoogle Scholar
  56. 56.
    Woods GL, Walker DH. Detection of infection or infectious agents by use of cytologic and histologic stains. Clin Microbiol Rev 1996; 9: 382–404.PubMedGoogle Scholar
  57. 57.
    Gleaves CA, Hodinka RL, Johnston SLG, Swierkosz EM. Laboratory diagnosis of viral infections. Coordinating ed. EJ Baron. Washington D.C. American Society for Microbiology 1994.Google Scholar
  58. 58.
    Gwaltney JM, Colonno RJ, Hamparian VV, Turner RB. Rhinovirus. In N.J. Schmidt and R.W. Emmons editors. Diagnostic procedures for viral, rickettsia) and chlamidial infections. 6di ed. American Public Health Association. Washington 1989; 579–614.Google Scholar
  59. 59.
    Espy MJ, Smith, Harmon MW, Kendal AP. Rapid detection of influenza virus by shell-vial assay with monoclonal antibodies. J Clin Microbiol 1986; 24: 677–679.PubMedGoogle Scholar
  60. 60.
    Halstead DC, Todd S, Fritch G. Evaluation of five methods for respiratory syncytial virus detection. J Clin Microbiol 1990; 28: 1021–1025.PubMedGoogle Scholar
  61. 61.
    Engler H D, Preuss J. Laboratory diagnosis of respiratory virus infections in 24 hours by utilizing shell vial cultures. J Clin Microbiol 1997; 2165–2167.Google Scholar
  62. 62.
    Waner J L. Detection of Respiratory Viruses: Is There a Need for Molecular Methods? Clinical Microbiology Newsletter 1999; 21 (10): 80–82.CrossRefGoogle Scholar
  63. 63.
    World Health Organization. Rapid laboratory techniques for the diagnosis of viral infections. Report of a WHO scientific group. WHO Tech Rep Ser 1981; 1–65.Google Scholar
  64. 64.
    Gardner PS, McQuillin J. Rapid virus diagnosis. “Application of immunofluorescence. 2” ed. London. Butterworths 1980.Google Scholar
  65. 65.
    Minnich L, Ray CG. Comparison of direct and indirect immunofluorescence staining of clinical specimens for detection of respiratory syncytial virus antigen. J Clin Microbiol 1982; 15: 969–970.PubMedGoogle Scholar
  66. 66.
    Hers JF. Fluorescent antibody technique in respiratory viral disease. Am Rev Resp Dis 1963; 88 supl: 316.PubMedGoogle Scholar
  67. 67.
    Gardner PS, McQuillin J. Application of the immunofluorescence antibody technique in the rapid diagnosis of respiratory syncytial virus infection. Br Med J 1968; 2: 340–343.CrossRefGoogle Scholar
  68. 68.
    Minnich L, Ray G. Comparison of direct immunofluorescent staining of clinical specimens for respiratory virus antigens with conventional isolation techniques. J Clin Microbiol 1980; 12: 391–394.PubMedGoogle Scholar
  69. 69.
    Ray CG, Minnich LL. Efficiency of immunofluorescence for rapid detection of common respiratory viruses. J Clin Microbiol 1987; 25: 355–357.PubMedGoogle Scholar
  70. 70.
    Blanding JG, Hoshiko MG, Stutman HR. Routine viral culture for pediatric respiratory specimens submitted for direct immunofluorescence testing. J Clin Microbiol 1989; 27: 1438–1440.PubMedGoogle Scholar
  71. 71.
    Takimoto S, Grandien M, Ishida MA, et al. Comparison of enzyme-immunoassay, indirect immunofluorescence assay, and virus isolation for detection of respiratory viruses in nasopharyngeal secretions. J Clin Microbiol 1991; 29: 470–474.PubMedGoogle Scholar
  72. 72.
    Stout C, Murphy MD, Lawrence S, Julian S. Evaluation of a monoclonal antibody pool for diagnosis of respiratory viral infections. J Clin Microbiol 1989; 27: 448–452.PubMedGoogle Scholar
  73. 73.
    Steed LL, Salmon VC, Overall JC. Identification of influenza A virus by shell-vial culture and two commercially available antigen detection methods. Clin Diagn Virol 1994; 2: 261–269.PubMedCrossRefGoogle Scholar
  74. 74.
    Leonardi GP, Leib H, Birkhead GS, Smith C, Costello P, Conron W. Comparison of rapid detection methods for influenza A virus and their value in health-care management of institutionalized geriatric patients. J Clin Microbiol 1994; 32: 70–74.PubMedGoogle Scholar
  75. 75.
    Dominguez EA, Taber LH, Couch RB. Comparison of rapid diagnostic techniques for respiratory syncytial and influenza A virus respiratory infections in young children. J Clin Microbiol 1993; 31: 2286–2290.PubMedGoogle Scholar
  76. 76.
    Ryan-Poirier KA, Katz JM, Webster RG, Kawaoka Y. Application of Directigen FLU-A for the detection of influenza a virus in human and nonhuman specimens. J Clin Microbiol 1992; 30: 1072–1075.PubMedGoogle Scholar
  77. 77.
    Lipson SM, Krilov LR. Comparison of the rapid second generation directigen EIA with cell culture and immunofluorescence for the detection of respiratory syncytial virus in nasopharyngeal aspirates. Clin Diagn Virol 1994; 2: 105–112.PubMedCrossRefGoogle Scholar
  78. 78.
    McIntosh K, McQuillin J, Reed SE, Gardner PS. Diagnosis of human coronavirus infection by immunofluorescence: method and application to respiratory disease in hospitalized children. J Med Virol 1978; 2:341–346.PubMedCrossRefGoogle Scholar
  79. 79.
    Macnaughton MR, Flowers D, Isaacs D. Diagnosis of human coronavirus infections in children using enzyme-linked immunosorbent assay. J Med Virol 1983; 11:319–325.PubMedCrossRefGoogle Scholar
  80. 80.
    Ieven M, Goossens H. Relevance of Nucleic Acid Amplification Techniques for Diagnosis of Respiratory Tract Infections in the Clinical Laboratory. Clin Microbiol Rev 1997; 10: 242–256.PubMedGoogle Scholar
  81. 81.
    Lönnrot M, Sjöroos M, Salminen K, Maaronen M, Hyypiä T, Hyöty H. Diagnosis of enterovirus and rhinovirus infections by RT-PCR and time-resolved fluorometry with lanthanide chelate labeled probes. J Med Virol 1999; 59: 378–384.PubMedCrossRefGoogle Scholar
  82. 82.
    Arruda E, Hayden FG. Detection of human rhinovirus RNA in nasal washings by PCR. Mol Cell Probes; 1993; 7: 373–379.PubMedCrossRefGoogle Scholar
  83. 83.
    Freymuth F, Vabret A, Galateau-Salle F et al. Detection of respiratory syncytial virus, parainfluenzavirus 3, adenovirus and rhinovirus sequences in respiratory tract of infants by polymerise chain reaction and hybridization. Clin Diagn Virol 1997; 8: 31–40.PubMedCrossRefGoogle Scholar
  84. 84.
    Vikerfors T, Lindegren G, Grandien M, van der Logt J. Diagnosis of influenza A virus infections by detection of specific immunoglobulins M, A, and G in serum. J Clin Microbiol 1989; 27: 453–458.PubMedGoogle Scholar
  85. 85.
    Meddens MJ, Herbrink P, Lindeman J, van Dijk WC. Serodiagnosis of respiratory syncytial virus (RSV) infection in children as measured by detection of RSV-specific immunoglobulins G, M, and A with enzyme-linked immunosorbent assay. J Clin Microbiol 1990; 28:152–155.PubMedGoogle Scholar
  86. 86.
    van der Logt JTM, van Loon AM, van der Veen J. Detection of parainfluenza IgM antibody by hemadsorption immunosorbent technique. J Med Virol 1982; 10: 213–221.PubMedCrossRefGoogle Scholar
  87. 87.
    Mostow SR, SchildG C, Dowdle WR, Wood RI. Application of the single radial diffusion test for assay of antibody to influenza type A viruses. J Clin Microbiol 1975; 2: 537–540.Google Scholar
  88. 88.
    Madore HP, Reichman RC, Dolin R. Serum antibody responses in naturally occurring influenza A virus infection determined by enzyme linked immunosorbent assay, hemagglutination inhibition and complement fixation. J Clin Microbiol 1983; 18: 1345–1350.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Núria Rabella
    • 1
  1. 1.Servei de Microbiologia. Hospital de la Santa Creu i Sant PauBarcelonaSpain

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