Respiratory Instability and Variability: Why is Respiration Such a Mess?
Although the terms “instability” and “variability” are often used synonymously, the respiratory control system does not have to be unstable for it to produce variable ventilatory patterns. A wide range of physiological mechanisms could lead to respiratory variability, such as fluctuations in state or behavioral inputs, cardiovascular and cerebrovascular influences, time-varying changes in the chemoreflexes, and nonlinear behavior of the central pattern generator. The panel of experts we have assembled here will discuss their latest views on these mechanisms, and comment on how these views have influenced and continue to influence the modeling of the control of breathing.
KeywordsCentral Pattern Generator Ventilatory Response Autocorrelative Structure Peripheral Chemoreceptor Respiratory Instability
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